About: The Tumor Suppressor Gene PTEN Plays a Role in Cell Cycle Regulation and Apoptosis in Prostate Cancer Cell Lines     Goto   Sponge   NotDistinct   Permalink

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Description
  • Phosphatase and tension homology deleted on chromosome ten (PTEN) is a tumor suppressor gene with protein and lipid phosphatase activity frequently altered in several types of human cancers. Herein, we demonstrate the effect of transfected wild type (wt) PTEN and its mutants (mt) L57W, H123Y, G129R that have lost lipid and protein phosphatase activity; and G129E characterized by loss of only lipid phosphatase activity, during the cell cycle and on apoptosis.
  • Phosphatase and tension homology deleted on chromosome ten (PTEN) is a tumor suppressor gene with protein and lipid phosphatase activity frequently altered in several types of human cancers. Herein, we demonstrate the effect of transfected wild type (wt) PTEN and its mutants (mt) L57W, H123Y, G129R that have lost lipid and protein phosphatase activity; and G129E characterized by loss of only lipid phosphatase activity, during the cell cycle and on apoptosis. (en)
  • Fosfatáza a homologie pnutí odstraněné na desátém chromozomu (PTEN) je tumor potlačující gen, u kterého je aktivita fosfatázy proteinu a lipidu často pozměněna a to hned u několika typů rakoviny člověka. Touto studií se pokoušíme demonstrovat vliv transfektovaného přirozeného typu (wt) PTEN a jeho mutací (mt) L57W, H123Y, G129R, které ztratily aktivitu fosfatázy proteinu a lipidu, a G129E charakterizovaný pouze ztrátou aktivity fosfatáze lipidu, a to během buněčného cyklu a při apoptóze. (cs)
Title
  • The Tumor Suppressor Gene PTEN Plays a Role in Cell Cycle Regulation and Apoptosis in Prostate Cancer Cell Lines
  • The Tumor Suppressor Gene PTEN Plays a Role in Cell Cycle Regulation and Apoptosis in Prostate Cancer Cell Lines (en)
  • Nádorový supresorový gen PTEN hraje úlohu v regulaci buněčného cyklu a apoptózy v prostatických nádorových linií. (cs)
skos:prefLabel
  • The Tumor Suppressor Gene PTEN Plays a Role in Cell Cycle Regulation and Apoptosis in Prostate Cancer Cell Lines
  • The Tumor Suppressor Gene PTEN Plays a Role in Cell Cycle Regulation and Apoptosis in Prostate Cancer Cell Lines (en)
  • Nádorový supresorový gen PTEN hraje úlohu v regulaci buněčného cyklu a apoptózy v prostatických nádorových linií. (cs)
skos:notation
  • RIV/61989592:15110/04:00006060!RIV09-MZ0-15110___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(NC6779), Z(MSM 151100001)
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 590965
http://linked.open...ai/riv/idVysledku
  • RIV/61989592:15110/04:00006060
http://linked.open...riv/jazykVysledku
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  • PTEN/MMAC; phosphatase; cell cycle (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...ontrolniKodProRIV
  • [C6286253C9F9]
http://linked.open...i/riv/mistoVydani
  • Heidelberg
http://linked.open...i/riv/nazevZdroje
  • Hormonal Carcinogenesis - Proceeding of the 4th International Symposium
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...iv/tvurceVysledku
  • Kolář, Zdeněk
  • Šváchová, Michaela
  • Hlobilková, Alice
  • Knillová, Jana
  • Řiháková, Petra
  • Guldberg, Per
  • Pimrová, Eva
http://linked.open...n/vavai/riv/zamer
number of pages
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  • Springer-Verlag
https://schema.org/isbn
  • 0-387-23783-6
http://localhost/t...ganizacniJednotka
  • 15110
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