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| Description
| - Vyšetřeli jsme soubor 30 pacientů v době diagnosy mantle cell lymfomu (MCL) metodou komparativní genomové hybridizace (CGH). Výsledky metodou CGH byly doplněny vyšetřením metodami klasické cytogeneticky, metodou FISH, PCR a dva nemocní byli vyšetřeni metodou array CGH. Použitím metod klasické cytogenetiky, FISH a PCR, chromosomové změny byly detekovány u 28 (93%) pacientů. Metodou CGH byly určeny nebalancované změny u 24 (80%) pacientů. Nejčastější nebalancované změny spojené se ztrátou genetického materiálu postihovaly chromosomy 1p(8 pacientů), 8p(10 pacientů), 9q (6 pacientů),11q(11 pacientů), 13q(10 pacientů), a 17p(9 pacientů), zatím co zmnožení genetického materiálu bylo nejčastěji pozorováno na chromosomech 3q(12 pacientů) a 8q(7 pacientů). Celkem bylo určeno 116 ztrát a 60 zmnožení genetického materiálu. Primární chromosomová změna t(11;14) byla metodou FISH a nebo PCR určena u 20(66,6%) pacientů a u 9 z nich byl zlom lokalizován v oblasti MTC. Hodnocení frekvence změn u nemocných s a bez t (cs)
- Comparative genomic hybridization (CGH) was carried out in 30 mantle cell lymphoma (MCL) patients at the time of diagnosis. CGH results were supported by conventional cytogenetics (CC), FISH, molecular genetic PCR methods and 2 patients were examined by array CGH. Using all cytogenetic, molecular cytogenetic and PCR methods, chromosomal changes were detected in 28 (93 %) patients. Using CGH, unbalanced chromosomal changes were detected in 24 ( (80 %) cases. The most frequent aberrations were losses of 1p (8 cases), 8p (10 cases), 9q (6 cases), 11q (11 cases), 13q (10 cases) and 17p (9 cases), and gains of chromosome 3 and 3q (12 cases) and 8q (7 cases). Total number of 60 gains and 116 losses were detected. The primary chromosomal change t(11, 14) was detected using FISH and/or PCR in 20 (66.6 %) patients, and in 9 of them, the breakpoint was determined using PCR in the major translocation cluster (MTC). The evaluation of the frequencies of CGH changes in groups of patients with and without t(11, 14)
- Comparative genomic hybridization (CGH) was carried out in 30 mantle cell lymphoma (MCL) patients at the time of diagnosis. CGH results were supported by conventional cytogenetics (CC), FISH, molecular genetic PCR methods and 2 patients were examined by array CGH. Using all cytogenetic, molecular cytogenetic and PCR methods, chromosomal changes were detected in 28 (93 %) patients. Using CGH, unbalanced chromosomal changes were detected in 24 ( (80 %) cases. The most frequent aberrations were losses of 1p (8 cases), 8p (10 cases), 9q (6 cases), 11q (11 cases), 13q (10 cases) and 17p (9 cases), and gains of chromosome 3 and 3q (12 cases) and 8q (7 cases). Total number of 60 gains and 116 losses were detected. The primary chromosomal change t(11, 14) was detected using FISH and/or PCR in 20 (66.6 %) patients, and in 9 of them, the breakpoint was determined using PCR in the major translocation cluster (MTC). The evaluation of the frequencies of CGH changes in groups of patients with and without t(11, 14) (en)
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| Title
| - Vysoká incidence nebalancovaných chromosomových změn u mantle cell lymfomu určené metodou komparativní genomové hybridizace. (cs)
- High Incidence of Unbalanced Chromosomal Changes in Mantle Cell Lymphoma Detected by Comparative Genomic Hybridization
- High Incidence of Unbalanced Chromosomal Changes in Mantle Cell Lymphoma Detected by Comparative Genomic Hybridization (en)
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| skos:prefLabel
| - Vysoká incidence nebalancovaných chromosomových změn u mantle cell lymfomu určené metodou komparativní genomové hybridizace. (cs)
- High Incidence of Unbalanced Chromosomal Changes in Mantle Cell Lymphoma Detected by Comparative Genomic Hybridization
- High Incidence of Unbalanced Chromosomal Changes in Mantle Cell Lymphoma Detected by Comparative Genomic Hybridization (en)
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| skos:notation
| - RIV/61989592:15110/04:00006059!RIV09-MZ0-15110___
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
| - Novosadová, Alena
- Raida, Luděk
- PAPAJÍK, Tomáš
- Faber, Edgar
- INDRÁK, Karel
- Jarošová, Marie
- Divoká, Martina
- Pospíšilová, Helena
- Prekopová, Ivana
- Pikalová, Zuzana
- Holzerová, Milena
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/61989592:15110/04:00006059
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - Comparative genomic hybridization; mantle cell lymphoma; t(11, 14); CCND1 gene FISH (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
| - GB - Spojené království Velké Británie a Severního Irska
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...vavai/riv/projekt
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| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Dušek, L.
- Faber, Edgar
- Indrák, Karel
- Jarošová, Marie
- Pikalová, Zuzana
- Raida, Luděk
- Divoká, Martina
- Papajík, Tomáš
- Pospíšilová, Helena
- Holzerová, Milena
- Prekopová, Ivana
- Lakomá, Ilona
- Novosadová, Alena
- Vlachová, Šárka
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| issn
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| number of pages
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| http://localhost/t...ganizacniJednotka
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