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| Description
| - Objective: Exogenous hormonal manipulation may alter physiological cyclic pattern of endometrium. This article evaluates the effect of oral estrogen-progesterone substitution on the expression of estrogen and progesterone receptors and the level of apoptosis in the secretory endometrium of substituted cycles by comparison with natural cycles in the same patient.Methods: Serum levels of estradiol (E2), SHBG and progesterone (P) were determined and bioptic samples of endometrium were taken on the 5th and 7th day of luteal phase in 26 infertile women who entered the assisted reproduction program first in a spontaneous and later in an estrogen-progestagen substituted cycle. E and P receptors (ER and PR) were estimated by immunostaining and image analysis in stroma and glandular epithelium. The level of apoptosis was evaluated by the TUNEL assay. Wilcoxon matched-pairs test was used for the statistical analysis of data.Results: The mean serum levels of E2, SHBG and P were higher in substituted cycles;
- Objective: Exogenous hormonal manipulation may alter physiological cyclic pattern of endometrium. This article evaluates the effect of oral estrogen-progesterone substitution on the expression of estrogen and progesterone receptors and the level of apoptosis in the secretory endometrium of substituted cycles by comparison with natural cycles in the same patient.Methods: Serum levels of estradiol (E2), SHBG and progesterone (P) were determined and bioptic samples of endometrium were taken on the 5th and 7th day of luteal phase in 26 infertile women who entered the assisted reproduction program first in a spontaneous and later in an estrogen-progestagen substituted cycle. E and P receptors (ER and PR) were estimated by immunostaining and image analysis in stroma and glandular epithelium. The level of apoptosis was evaluated by the TUNEL assay. Wilcoxon matched-pairs test was used for the statistical analysis of data.Results: The mean serum levels of E2, SHBG and P were higher in substituted cycles; (en)
- Exogenní hormonální manipulace může mít vliv na změnu fyziologické cyklické struktury děložní sliznice. Tato studie hodnotí vliv orálně podávané náhrady estrogen-progesteronu na chování receptorů estrogenu a progesteronu a na hladinu apoptózy v sekrečním endometriu nahrazených cyklů v porovnání s přirozenými cykly u stejného pacienta. (cs)
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| Title
| - THE IMPACT OF ORAL ESTRADIOL AND PROGESTERONE SUBSTITUTION ON ESTROGEN AND PROGESTERONE RECEPTORS EXPRESSION AND APOPTOSIS IN HUMAN ENDOMETRIUM
- THE IMPACT OF ORAL ESTRADIOL AND PROGESTERONE SUBSTITUTION ON ESTROGEN AND PROGESTERONE RECEPTORS EXPRESSION AND APOPTOSIS IN HUMAN ENDOMETRIUM (en)
- Vliv estrogen-progestinové substituce na expresi estrogenových a progesteronových receptorů a apoptózu v lidském endometriu (cs)
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| skos:prefLabel
| - THE IMPACT OF ORAL ESTRADIOL AND PROGESTERONE SUBSTITUTION ON ESTROGEN AND PROGESTERONE RECEPTORS EXPRESSION AND APOPTOSIS IN HUMAN ENDOMETRIUM
- THE IMPACT OF ORAL ESTRADIOL AND PROGESTERONE SUBSTITUTION ON ESTROGEN AND PROGESTERONE RECEPTORS EXPRESSION AND APOPTOSIS IN HUMAN ENDOMETRIUM (en)
- Vliv estrogen-progestinové substituce na expresi estrogenových a progesteronových receptorů a apoptózu v lidském endometriu (cs)
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| skos:notation
| - RIV/61989592:15110/04:00002040!RIV06-MZ0-15110___
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| http://linked.open.../vavai/riv/strany
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/61989592:15110/04:00002040
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - estradiol; progesterone; hormonal substitution; apoptosis; steroid receptors (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...vavai/riv/projekt
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| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Březinová, Jana
- Fingerová, Helena
- Oborná, Ivana
- Havelka, Pavel
- Kršková, Milena
- Lichnovský, Václav
- Kubínyiová, Michaela
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| issn
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| number of pages
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| http://localhost/t...ganizacniJednotka
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