About: N-formyl-Met-Leu-Phe-induced oxidative burst in DMSO-differentiated HL-60 cells requires active Hsp90, but not intact microtubules.     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
Description
  • V této práci jsme studovali, zda jsou mikrotubuly a %22heat shock%22 protein 90 (Hsp90) v buňkách HL-60 diferencovaných dimethylsulfoxidem zapojeny do oxidativního vzplanutí aktivovaného 12-O-myristoylforbol-13-acetátem (PMA) a peptidem N-formyl-Met-Leu-Phe (fMLP). Výsledky ukázaly, že látky interagující s mikrotubuly, paklitaxel (1-5 #M), kolchicin (1-100 #M), nokodazol (1-20 #M) a vinkristin (1-50 #M), neovlivňují oxidativní vzplanutí aktivované PMA ani fMLP. Naproti tomu radicikol, inhibitor proteinu Hsp90, inhiboval časově a koncentračně závislým způsobem oxidativní vzplanutí aktivované fMLP, přičemž hodnota IC50 měla při preinkubaci 30 min hodnotu 16,5 # 3,5 #M. Z výsledků usuzujeme, že oxidativní vzplanutí v diferencovaných buňkách HL-60 aktivované PMA i fMLP je nezávislé na mikrotubulech a že vzplanutí vyvolané fMLP vyžaduje aktivitu Hsp90. (cs)
  • In this study we examined whether microtubules and heat shock protein 90 (Hsp90) are involved in phorbol myristate acetate (PMA) and N-formyl-Met-Leu-Phe (fMLP)-induced oxidative burst in DMSO-differentiated HL-60 cells. Our results showed that microtubule interfering agents, paclitaxel (1-5 microM), colchicine (1-100 microM), nocodazole (1-20 microM), and vincristine (1-50 microM), did not affect either PMA or fMLP-induced oxidative burst. In contrast, radicicol, an inhibitor of Hsp90, inhibited fMLP-induced oxidative burst in time and concentration-dependent manner where IC50 value for 30 min pre-incubation was 16.5 +/- 3.5 microM radicicol. We conclude that both PMA and fMLP-induced oxidative burst in DMSO-differentiated HL-60 cells is microtubule-independent while the latter requires Hsp90 activity.
  • In this study we examined whether microtubules and heat shock protein 90 (Hsp90) are involved in phorbol myristate acetate (PMA) and N-formyl-Met-Leu-Phe (fMLP)-induced oxidative burst in DMSO-differentiated HL-60 cells. Our results showed that microtubule interfering agents, paclitaxel (1-5 microM), colchicine (1-100 microM), nocodazole (1-20 microM), and vincristine (1-50 microM), did not affect either PMA or fMLP-induced oxidative burst. In contrast, radicicol, an inhibitor of Hsp90, inhibited fMLP-induced oxidative burst in time and concentration-dependent manner where IC50 value for 30 min pre-incubation was 16.5 +/- 3.5 microM radicicol. We conclude that both PMA and fMLP-induced oxidative burst in DMSO-differentiated HL-60 cells is microtubule-independent while the latter requires Hsp90 activity. (en)
Title
  • N-formyl-Met-Leu-Phe-induced oxidative burst in DMSO-differentiated HL-60 cells requires active Hsp90, but not intact microtubules.
  • N-formyl-Met-Leu-Phe-induced oxidative burst in DMSO-differentiated HL-60 cells requires active Hsp90, but not intact microtubules. (en)
  • Oxidativní vzplanutí aktivované peptidem N-formyl-Met-Leu-Phe vyžaduje v buňkách HL-60 diferencovaných dimethylsulfoxidem aktivní Hsp90, ale nevyžaduje neporušené mikrotubuly (cs)
skos:prefLabel
  • N-formyl-Met-Leu-Phe-induced oxidative burst in DMSO-differentiated HL-60 cells requires active Hsp90, but not intact microtubules.
  • N-formyl-Met-Leu-Phe-induced oxidative burst in DMSO-differentiated HL-60 cells requires active Hsp90, but not intact microtubules. (en)
  • Oxidativní vzplanutí aktivované peptidem N-formyl-Met-Leu-Phe vyžaduje v buňkách HL-60 diferencovaných dimethylsulfoxidem aktivní Hsp90, ale nevyžaduje neporušené mikrotubuly (cs)
skos:notation
  • RIV/61989592:15110/04:00002001!RIV06-MSM-15110___
http://linked.open.../vavai/riv/strany
  • 141-144
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • Z(MSM 151100003)
http://linked.open...iv/cisloPeriodika
  • 2
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 576255
http://linked.open...ai/riv/idVysledku
  • RIV/61989592:15110/04:00002001
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • Radicicol; Hsp90; Microtubules; Oxidative burst; HL-60 (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • CZ - Česká republika
http://linked.open...ontrolniKodProRIV
  • [F54B72B9E76C]
http://linked.open...i/riv/nazevZdroje
  • Biomedical Papers
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 148
http://linked.open...iv/tvurceVysledku
  • Vrba, Jiří
  • Modrianský, Martin
http://linked.open...n/vavai/riv/zamer
issn
  • 1213-8118
number of pages
http://localhost/t...ganizacniJednotka
  • 15110
Faceted Search & Find service v1.16.118 as of Jun 21 2024


Alternative Linked Data Documents: ODE     Content Formats:   [cxml] [csv]     RDF   [text] [turtle] [ld+json] [rdf+json] [rdf+xml]     ODATA   [atom+xml] [odata+json]     Microdata   [microdata+json] [html]    About   
This material is Open Knowledge   W3C Semantic Web Technology [RDF Data] Valid XHTML + RDFa
OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 48 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software