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| rdf:type
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| Description
| - V posledních letech bylo popsáno několik skupin proteinů zasahujících do regulace buněčné proliferace , diferenciace a buněčné smrti během ontogeneze. V naší studii jsme srovnávali výskyt některých proteinů přináležejících k Bcl-2, p53 a myc rodinám s proliferační aktivitou a úrovní apoptózy během vývoje epitelu lidského duodena. (cs)
- In last few years, numerous groups of proteins participating in the regulation of cell proliferation, differentiation and death during ontogenesis have been described. In this study we compared the occurrence of Bcl-2, p53 and myc protein families with the level of proliferative activity and apoptosis during development of duodenal epithelium. Paraffin embedded tissues of eight human embryos and foetuses aged from the 6th -18th week of IUD were used. For the detection of apoptotic cells the TUNEL method was performed, the proliferative marker PCNA and all the proteins studied were detected by means of indirect three-step immunohistochemical method.In the 6th and 8th week of intrauterine development we observed isolated TUNEL positive epithelial cells only and this was accompanied by the disperse presence of PCNA as well as by all the studied proteins: Bcl-2, Bax, Bcl-XL, c-myc, N-myc, p53, p63 and p73. In the early foetal period of duodenal development we registered changes in PCNA and TUNEL positiv
- In last few years, numerous groups of proteins participating in the regulation of cell proliferation, differentiation and death during ontogenesis have been described. In this study we compared the occurrence of Bcl-2, p53 and myc protein families with the level of proliferative activity and apoptosis during development of duodenal epithelium. Paraffin embedded tissues of eight human embryos and foetuses aged from the 6th -18th week of IUD were used. For the detection of apoptotic cells the TUNEL method was performed, the proliferative marker PCNA and all the proteins studied were detected by means of indirect three-step immunohistochemical method.In the 6th and 8th week of intrauterine development we observed isolated TUNEL positive epithelial cells only and this was accompanied by the disperse presence of PCNA as well as by all the studied proteins: Bcl-2, Bax, Bcl-XL, c-myc, N-myc, p53, p63 and p73. In the early foetal period of duodenal development we registered changes in PCNA and TUNEL positiv (en)
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| Title
| - Výskyt proteinů rodiny c-myc, p53 a Bcl-2 v časných fázích vývoje epitelu duodena. (cs)
- The occurrence of c-myc, p53 and Bcl-2 family proteins in the early phase of development of duodenal epithelium
- The occurrence of c-myc, p53 and Bcl-2 family proteins in the early phase of development of duodenal epithelium (en)
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| skos:prefLabel
| - Výskyt proteinů rodiny c-myc, p53 a Bcl-2 v časných fázích vývoje epitelu duodena. (cs)
- The occurrence of c-myc, p53 and Bcl-2 family proteins in the early phase of development of duodenal epithelium
- The occurrence of c-myc, p53 and Bcl-2 family proteins in the early phase of development of duodenal epithelium (en)
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| skos:notation
| - RIV/61989592:15110/04:00001965!RIV06-MSM-15110___
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| http://linked.open.../vavai/riv/strany
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/61989592:15110/04:00001965
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - Bcl-2 family; p53 family; myc; apoptosis; embryo; duodenum (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Erdösová, Běla
- Holinka, M.
- Kylarová, Dana
- Vrchovecký, J.
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| http://linked.open...n/vavai/riv/zamer
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| issn
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| number of pages
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| http://localhost/t...ganizacniJednotka
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