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  • The aim of our work was the detection of c- and N- myc proteins in the developing kidney of human fetuses especially in the neogenous zone. These proteins being localized in nucleus and encoded by the cellullar oncogene myc function as transcriptional factors. Myc gene represents the key control gene in the course of cellular proliferation and differentiation. It also participates in the regulation of apoptosis and the origin of some cancers. Both proteins have been proved to be inevitable for proper nephrogenesis in mice. Considering the dearth of studies dealing with human embryonic tissues, we attempted to map the localization and spatiotemporal relations of the expression of these proteins during human nephrogenesis. In addition, issuing from our previous observations, we tried to compare their ways of expression with those of Bcl-2 (antiapoptotic effect) and Bax (proapoptotic function) proteins. Histologically normal kidneys were collected from eight human fetuses ranging from the 10th-30th we
  • The aim of our work was the detection of c- and N- myc proteins in the developing kidney of human fetuses especially in the neogenous zone. These proteins being localized in nucleus and encoded by the cellullar oncogene myc function as transcriptional factors. Myc gene represents the key control gene in the course of cellular proliferation and differentiation. It also participates in the regulation of apoptosis and the origin of some cancers. Both proteins have been proved to be inevitable for proper nephrogenesis in mice. Considering the dearth of studies dealing with human embryonic tissues, we attempted to map the localization and spatiotemporal relations of the expression of these proteins during human nephrogenesis. In addition, issuing from our previous observations, we tried to compare their ways of expression with those of Bcl-2 (antiapoptotic effect) and Bax (proapoptotic function) proteins. Histologically normal kidneys were collected from eight human fetuses ranging from the 10th-30th we (en)
  • Cílem naší práce byla detekce proteinů c- a N- myc ve vyvíjející se ledvině lidských zárodků a zvláště v její neogenní zóně. Tyto proteiny lokalizované v jádře a kódované buněčným onkogenem myc fungují jako transkripční faktory. (cs)
Title
  • Detekce proteinů rodiny myc ve vyvíjející se lidské ledvině (cs)
  • The detection of MYC proteins in the developing human kidney
  • The detection of MYC proteins in the developing human kidney (en)
skos:prefLabel
  • Detekce proteinů rodiny myc ve vyvíjející se lidské ledvině (cs)
  • The detection of MYC proteins in the developing human kidney
  • The detection of MYC proteins in the developing human kidney (en)
skos:notation
  • RIV/61989592:15110/04:00001945!RIV06-MSM-15110___
http://linked.open.../vavai/riv/strany
  • 205-207
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • Z(MSM 151100001)
http://linked.open...iv/cisloPeriodika
  • 2
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 559968
http://linked.open...ai/riv/idVysledku
  • RIV/61989592:15110/04:00001945
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • Myc family; c-myc; N-myc; apoptosis; nephrogenesis; Bcl-2 family (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • CZ - Česká republika
http://linked.open...ontrolniKodProRIV
  • [D3AAE7610BA8]
http://linked.open...i/riv/nazevZdroje
  • Biomedical Papers
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 148
http://linked.open...iv/tvurceVysledku
  • Erdösová, Běla
  • Kylarová, Dana
  • Wagner, F.
http://linked.open...n/vavai/riv/zamer
issn
  • 1213-8118
number of pages
http://localhost/t...ganizacniJednotka
  • 15110
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