About: Interleukin 1alfa Single-Nucleotide Polymorphism Associated with Systemic Sclerosis

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	In systemic sclerosis (SSc), constitutive expression of the proinflammatory and fibrogenic cytokine interleukin 1a (IL-1a) by dermal fibroblasts from the affected skin has been observed. We investigated the association of a single-nucleotide polymorphism at position ?889 in the IL-1a gene in patients with SSc. Methods. Genotyping of IL-1a ?889 polymorphism was performed in 46 patients with SSc and in 150 healthy controls by polymerase chain reaction with sequence-specific primers. All subjects were unrelated Slovak Caucasians. Results. In SSc patients, carriers of the IL-1a ?889 T allele were significantly overrepresented in comparison with controls (63.0% vs 42.0%; p = 0.01, OR 2.3, 95% CI 1.2?4.6). The frequency of the IL-1a ?889 T allele was increased in SSc patients (38.0%) in comparison with controls (25.7%; p = 0.02). Conclusion. The IL-1a ?889 polymorphism, previously shown to predispose to increased IL-1 protein expression, may be involved in susceptibility to SSc. (J Rheumatol 2004;31 In systemic sclerosis (SSc), constitutive expression of the proinflammatory and fibrogenic cytokine interleukin 1a (IL-1a) by dermal fibroblasts from the affected skin has been observed. We investigated the association of a single-nucleotide polymorphism at position ?889 in the IL-1a gene in patients with SSc. Methods. Genotyping of IL-1a ?889 polymorphism was performed in 46 patients with SSc and in 150 healthy controls by polymerase chain reaction with sequence-specific primers. All subjects were unrelated Slovak Caucasians. Results. In SSc patients, carriers of the IL-1a ?889 T allele were significantly overrepresented in comparison with controls (63.0% vs 42.0%; p = 0.01, OR 2.3, 95% CI 1.2?4.6). The frequency of the IL-1a ?889 T allele was increased in SSc patients (38.0%) in comparison with controls (25.7%; p = 0.02). Conclusion. The IL-1a ?889 polymorphism, previously shown to predispose to increased IL-1 protein expression, may be involved in susceptibility to SSc. (J Rheumatol 2004;31 (en) U 46 slovenských pacientů se sklerodermií byl sledován polymorfismus genů rodiny IL-1. Byla zjištěna zvýšená frekvence alely T (38%) polymorfismu IL-1alfa ?889 ve srovnání s kontrolami (26%). Tento polymorfismus může být faktorem vnímavosti ke sklerodermii. (cs)
Title	Asociace SNP polymorfismu IL-1alfa se systémovou sklerózou (cs) Interleukin 1alfa Single-Nucleotide Polymorphism Associated with Systemic Sclerosis Interleukin 1alfa Single-Nucleotide Polymorphism Associated with Systemic Sclerosis (en)
skos:prefLabel	Asociace SNP polymorfismu IL-1alfa se systémovou sklerózou (cs) Interleukin 1alfa Single-Nucleotide Polymorphism Associated with Systemic Sclerosis Interleukin 1alfa Single-Nucleotide Polymorphism Associated with Systemic Sclerosis (en)
skos:notation	RIV/61989592:15110/04:00001781!RIV09-MSM-15110___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA310/99/1676), Z(MSM 151100002)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2009
http://linked.open...aciTvurceVysledku	HUTYROVÁ, Beáta
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Palackého v Olomouci / Lékařská fakulta
http://linked.open...dnocenehoVysledku	568662
http://linked.open...ai/riv/idVysledku	RIV/61989592:15110/04:00001781
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	SYSTEMIC SCLEROSIS; INTERLEUKIN 1; SINGLE-NUCLEOTIDE POLYMORPHISM; CASE-CONTROL STUDY; GENETIC SUSCEPTIBILITY (en)
http://linked.open.../riv/klicoveSlovo	CASE-CONTROL STUDY INTERLEUKIN 1 SINGLE-NUCLEOTIDE POLYMORPHISM SYSTEMIC SCLEROSIS GENETIC SUSCEPTIBILITY
http://linked.open...odStatuVydavatele	CA - Kanada
http://linked.open...ontrolniKodProRIV	[D3B84FC3685F]
http://linked.open...i/riv/nazevZdroje	Journal of Rheumatology (online)
http://linked.open...in/vavai/riv/obor	FN
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	Immunogenetics of lung inflammation: VNTR polymorphims of IL-1RA (IL-1 receptor antagonist) gene and pulmonary fibrosis (idiopathic, secondary)
http://linked.open...UplatneniVysledku	2004
http://linked.open...v/svazekPeriodika	31
http://linked.open...iv/tvurceVysledku	Petřek, Martin du Bois, Roland M. Hutyrová, Beáta Bosák, Vladimír Buc, Milan Lukác, Josef
http://linked.open...n/vavai/riv/zamer	http://linked.opendata.cz/resource/domain/vavai/zamer/MSM%20151100002
issn	1499-2752
number of pages	4 (xsd:int)
http://localhost/t...ganizacniJednotka	15110

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