About: Phenolics-rich extracts from Silybum marianum and Prunella vulgaris reduce a high-sucrose diet induced oxidative stress in hereditary hypertriglyceridemic rats     Goto   Sponge   NotDistinct   Permalink

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Description
  • Na polyfenoly bohaté extrakty ze Silybum marianum a Prunelly vulgaris snižují vysokocukrovou dietou indukovaný oxidační stres u hereditárních hypetriglyceridemických potkanů. (cs)
  • The study tested the effects of phenolics-rich extracts from the plants Silybum marianum (silymarin) and Prunella vulgaris (PVE) on blood and liver antioxidant status and lipoprotein metabolism. Hereditary hypertriglyceridemic rats fed on standard diet (STD) or high-sucrose diet (HSD, 70cal% of sucrose) for two weeks were used. HSD doubled plasma and liver triacylglycerol (TAG) and increased plasma VLDL-TAG and VLDL-cholesterol compared to STD. Administration of silymarin or PVE as 1% dietary supplements in HSD did not influence lipid levels in plasma or liver, but both extracts caused decrease in plasma VLDL-cholesterol levels. HSD-induced oxidative stress was manifested in increased TBARS and conjugated dienes (CD) content, decreased GSH levels and glutathione peroxidase (GPX) activity in blood and liver. In blood the activity of superoxide dismutase (SOD) decreased, whereas in liver the activity of catalase increased after HSD. Feeding on HSD containing phenolics-rich extracts resulted in reduction
  • The study tested the effects of phenolics-rich extracts from the plants Silybum marianum (silymarin) and Prunella vulgaris (PVE) on blood and liver antioxidant status and lipoprotein metabolism. Hereditary hypertriglyceridemic rats fed on standard diet (STD) or high-sucrose diet (HSD, 70cal% of sucrose) for two weeks were used. HSD doubled plasma and liver triacylglycerol (TAG) and increased plasma VLDL-TAG and VLDL-cholesterol compared to STD. Administration of silymarin or PVE as 1% dietary supplements in HSD did not influence lipid levels in plasma or liver, but both extracts caused decrease in plasma VLDL-cholesterol levels. HSD-induced oxidative stress was manifested in increased TBARS and conjugated dienes (CD) content, decreased GSH levels and glutathione peroxidase (GPX) activity in blood and liver. In blood the activity of superoxide dismutase (SOD) decreased, whereas in liver the activity of catalase increased after HSD. Feeding on HSD containing phenolics-rich extracts resulted in reduction (en)
Title
  • Phenolics-rich extracts from Silybum marianum and Prunella vulgaris reduce a high-sucrose diet induced oxidative stress in hereditary hypertriglyceridemic rats
  • Phenolics-rich extracts from Silybum marianum and Prunella vulgaris reduce a high-sucrose diet induced oxidative stress in hereditary hypertriglyceridemic rats (en)
  • Extrakty bohaté na fenoly ze Silybum marianum a Prunella vulgaris redukují oxidační stres vyvolaný u hereditárně hypertriglyceridemických potkanů krmených vysokosacharosovou dietou (cs)
skos:prefLabel
  • Phenolics-rich extracts from Silybum marianum and Prunella vulgaris reduce a high-sucrose diet induced oxidative stress in hereditary hypertriglyceridemic rats
  • Phenolics-rich extracts from Silybum marianum and Prunella vulgaris reduce a high-sucrose diet induced oxidative stress in hereditary hypertriglyceridemic rats (en)
  • Extrakty bohaté na fenoly ze Silybum marianum a Prunella vulgaris redukují oxidační stres vyvolaný u hereditárně hypertriglyceridemických potkanů krmených vysokosacharosovou dietou (cs)
skos:notation
  • RIV/61989592:15110/04:00000932!RIV/2005/MZ0/151105/N
http://linked.open.../vavai/riv/strany
  • 123-130
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(NL6713)
http://linked.open...iv/cisloPeriodika
  • 2
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 579355
http://linked.open...ai/riv/idVysledku
  • RIV/61989592:15110/04:00000932
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • Silymarin;Prunella vulgaris;antioxidant status;hypertriglyceridemia;lipoprotein profile;high-sucrose diet (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • NL - Nizozemsko
http://linked.open...ontrolniKodProRIV
  • [3D76DB4F322F]
http://linked.open...i/riv/nazevZdroje
  • Pharmacological Research
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 50
http://linked.open...iv/tvurceVysledku
  • Kazdová, L.
  • Ulrichová, Jitka
  • Večeřa, Rostislav
  • Škottová, Nina
  • Sobolová, L.
  • Oliarnyk, O.
issn
  • 1043-6618
number of pages
http://localhost/t...ganizacniJednotka
  • 15110
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