| Attributes | Values |
|---|
| rdf:type
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| Description
| - Mezidruhové rozdíly v glykosidaci v savčích tkáních ukazují na nejednoznačnosti při extrapolaci endobiotických a xenobiotických cest ze zvířat na člověka. (cs)
- Interspecies differences in glycosidation potential in mammalian tissues represent a factor contributing to ambiguity when endobiotic and/or xenobiotic metabolic pathways are extrapolated from animals to man. Using the TLC/autoradiographic technique, we conducted an in vitro investigation involving mouse, rat, monkey, as well as human liver and kidney microsomes to evaluate their glycoconjugation potential towards (3)H-labeled, purine-derived selective inhibitors of cyclin-dependent kinases such as olomoucine, bohemine, roscovitine, 6-(2-hydroxybenzyl)amino-2-(1-hydroxymethyl-2-methylpropyl)amino-9-isopropylpurine (compound A-4), and 6-(3-hydroxybenzyl)amino-2-[(1(R/S)-hydroxymethyl)propyl]amino-9-isopropylpurine (compound A-5) as aglycones. Principally, this study confirmed the aliphatic hydroxyl group of olomoucine-type inhibitors as a relatively suitable target for glucuronide, glucoside, xyloside, galactoside, and/or N-acetylaminoglucoside conjugation. Of the tissues examined, only the mouse micro
- Interspecies differences in glycosidation potential in mammalian tissues represent a factor contributing to ambiguity when endobiotic and/or xenobiotic metabolic pathways are extrapolated from animals to man. Using the TLC/autoradiographic technique, we conducted an in vitro investigation involving mouse, rat, monkey, as well as human liver and kidney microsomes to evaluate their glycoconjugation potential towards (3)H-labeled, purine-derived selective inhibitors of cyclin-dependent kinases such as olomoucine, bohemine, roscovitine, 6-(2-hydroxybenzyl)amino-2-(1-hydroxymethyl-2-methylpropyl)amino-9-isopropylpurine (compound A-4), and 6-(3-hydroxybenzyl)amino-2-[(1(R/S)-hydroxymethyl)propyl]amino-9-isopropylpurine (compound A-5) as aglycones. Principally, this study confirmed the aliphatic hydroxyl group of olomoucine-type inhibitors as a relatively suitable target for glucuronide, glucoside, xyloside, galactoside, and/or N-acetylaminoglucoside conjugation. Of the tissues examined, only the mouse micro (en)
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| Title
| - In vitro glycosidation potential towards Olomoucine - type cyclin-dependent kinase inhibitors in rodent and primate microsomes
- In vitro glycosidation potential towards Olomoucine - type cyclin-dependent kinase inhibitors in rodent and primate microsomes (en)
- Glykosidace in vitro za účelem inhibitoru cyklin dependentní kinázy olomoucinového typu a v mikrosomech hlodavců a primátů (cs)
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| skos:prefLabel
| - In vitro glycosidation potential towards Olomoucine - type cyclin-dependent kinase inhibitors in rodent and primate microsomes
- In vitro glycosidation potential towards Olomoucine - type cyclin-dependent kinase inhibitors in rodent and primate microsomes (en)
- Glykosidace in vitro za účelem inhibitoru cyklin dependentní kinázy olomoucinového typu a v mikrosomech hlodavců a primátů (cs)
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| skos:notation
| - RIV/61989592:15110/03:00007270!RIV09-MSM-15110___
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| http://linked.open...avai/riv/aktivita
| |
| http://linked.open...avai/riv/aktivity
| - P(GA301/02/0475), P(OC B17.20), V, Z(MSM 151100001)
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
| |
| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
| |
| http://linked.open...ai/riv/idVysledku
| - RIV/61989592:15110/03:00007270
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - glycosidation; mouse; rat; monkey; human; CDK inhibitors (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
| - Physiological Research (print)
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| http://linked.open...in/vavai/riv/obor
| |
| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
| |
| http://linked.open...vavai/riv/projekt
| |
| http://linked.open...UplatneniVysledku
| |
| http://linked.open...v/svazekPeriodika
| |
| http://linked.open...iv/tvurceVysledku
| - Havlíček, Libor
- Hanuš, Jan
- Veselý, Jaroslav
- Rypka, Miroslav
- Fuksová, Květoslava
- Černý, B.
- Chmela, Zdeněk
- Riegrová, Dagmar
- Belejová, Marie
- Červenková, Kateřina
- Michalíková, K.
- Brejcha, A.
- Michnová, K.
- Šúrová, I.
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| http://linked.open...n/vavai/riv/zamer
| |
| issn
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| number of pages
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| http://localhost/t...ganizacniJednotka
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