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| rdf:type
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| Description
| - For the development of new drugs, evaluation of drug-drug interactions with already known compounds, as well as for better understanding of metabolism pathways of various toxicants and pollutants, we studied the drug metabolism mediated by cytochromes P450. The experimental approach is based on animal drug-metabolising systems. From the ethical as well as rational reasons, the selection of an appropriate system is crucial. Here, it is necessary to decide on the basis of expected CYP system involved. For CYP1A-mediated pathways, all the commonly used experimental models are appropriate except probably the dog. On the contrary, the dog seems to be suitable for modelling of processes depending on the CYP2D. With CYP2C, which is possibly the most large and complicated subfamily, the systems based on monkey (Maccacus rhesus) may be a good representative. The CYP3A seems to be well modelled by pig or minipig CYP3A29. Detailed studies on activities with individual isolated CYP forms are needed to understand
- For the development of new drugs, evaluation of drug-drug interactions with already known compounds, as well as for better understanding of metabolism pathways of various toxicants and pollutants, we studied the drug metabolism mediated by cytochromes P450. The experimental approach is based on animal drug-metabolising systems. From the ethical as well as rational reasons, the selection of an appropriate system is crucial. Here, it is necessary to decide on the basis of expected CYP system involved. For CYP1A-mediated pathways, all the commonly used experimental models are appropriate except probably the dog. On the contrary, the dog seems to be suitable for modelling of processes depending on the CYP2D. With CYP2C, which is possibly the most large and complicated subfamily, the systems based on monkey (Maccacus rhesus) may be a good representative. The CYP3A seems to be well modelled by pig or minipig CYP3A29. Detailed studies on activities with individual isolated CYP forms are needed to understand (en)
- Pro vývoj nových léčiv, vyhodnocení možných lékových interakcí a z důvodů lepšího poznání metabolických přeměn různých toxických látek, jsme studovali metabolismus xenobiotik probíhající za účasti cytochromů P450. Experimentální přístup je založen na využití zvířecích enzymů metabolizujících léčiva. Z etických i praktických důvodů je zcela zásadní otázkou výběr vhodného experimentálního zvířete. Zde je třeba vědět, jaká forma cytochromu P450 se účastní metabolických přeměn. Pro metabolické přeměny spojené s CYP1A jsou vhodná všechna experimentální zvířata kromě psa. Na druhé straně pes je dobrý model pro metabolické přeměny spojené s CYP2D. Pro podrodinu CYP2C, která je jednou z nejkomplikovanějších, se zdá být dobrým modelovým zvířetem opice (Maccacus rhesus). Pro lidský CYP3A je vhodným modelovým enzymem prasečí nebo miniprasečí CYP3A29. K porozumění všem aspektům mezidruhových odlišností je třeba detailně studovat aktivity individuálních izolovaných forem CYP. (cs)
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| Title
| - Cytochromes P450 and experimental models of drug metabolism
- Cytochromes P450 and experimental models of drug metabolism (en)
- Cytochromy P-450 a experimentální modely lékového metabolismu (cs)
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| skos:prefLabel
| - Cytochromes P450 and experimental models of drug metabolism
- Cytochromes P450 and experimental models of drug metabolism (en)
- Cytochromy P-450 a experimentální modely lékového metabolismu (cs)
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| skos:notation
| - RIV/61989592:15110/02:00007271!RIV09-MSM-15110___
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| http://linked.open...avai/riv/aktivita
| |
| http://linked.open...avai/riv/aktivity
| - P(OC B15.50), Z(MSM 151100003)
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| http://linked.open...iv/cisloPeriodika
| |
| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
| |
| http://linked.open...ai/riv/idVysledku
| - RIV/61989592:15110/02:00007271
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| http://linked.open...riv/jazykVysledku
| |
| http://linked.open.../riv/klicovaSlova
| - Cytochrome P450; drug metabolism; inter-species differences (en)
|
| http://linked.open.../riv/klicoveSlovo
| |
| http://linked.open...odStatuVydavatele
| |
| http://linked.open...ontrolniKodProRIV
| |
| http://linked.open...i/riv/nazevZdroje
| - Journal of Cellular and Molecular Medicine
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| http://linked.open...in/vavai/riv/obor
| |
| http://linked.open...ichTvurcuVysledku
| |
| http://linked.open...cetTvurcuVysledku
| |
| http://linked.open...vavai/riv/projekt
| |
| http://linked.open...UplatneniVysledku
| |
| http://linked.open...v/svazekPeriodika
| |
| http://linked.open...iv/tvurceVysledku
| - Anzenbacher, Pavel
- Anzenbacherová, Eva
- Zuber, Roman
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| http://linked.open...n/vavai/riv/zamer
| |
| issn
| |
| number of pages
| |
| http://localhost/t...ganizacniJednotka
| |
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