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| Description
| - New soluble derivatives of the hepatoprotective flavonolignan silybin (1), namely silybin galactoside (2), glucoside (3), lactoside (4) and maltoside (5) were investigated for their radical scavenging and antilipoperoxidation properties. According to cyclic voltammetry the results show that glycosides are weaker electron donors than silybin, although it was of interest that they were found to be more potent scavengers of the 1,1-diphenyl-2-picrylhydrazyl and the 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid)-derived radicals. The glycosides (2)-(5) were more efficient than silybin in preventing tert-butylhydroperoxide-induced lipoperoxidation of rat liver mitochondrial membranes. Furthermore, glycosides (2)-(5) were significantly more cytoprotective than silybin in tert-butylhydroperoxide-damaged rat erythrocytes and primary hepatocyte cultures. Glycosylation of silybin substantially reduced its toxic effects in primary cultured hepatocytes observed during prolonged incubation. These res
- New soluble derivatives of the hepatoprotective flavonolignan silybin (1), namely silybin galactoside (2), glucoside (3), lactoside (4) and maltoside (5) were investigated for their radical scavenging and antilipoperoxidation properties. According to cyclic voltammetry the results show that glycosides are weaker electron donors than silybin, although it was of interest that they were found to be more potent scavengers of the 1,1-diphenyl-2-picrylhydrazyl and the 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid)-derived radicals. The glycosides (2)-(5) were more efficient than silybin in preventing tert-butylhydroperoxide-induced lipoperoxidation of rat liver mitochondrial membranes. Furthermore, glycosides (2)-(5) were significantly more cytoprotective than silybin in tert-butylhydroperoxide-damaged rat erythrocytes and primary hepatocyte cultures. Glycosylation of silybin substantially reduced its toxic effects in primary cultured hepatocytes observed during prolonged incubation. These res (en)
- Nové rozpustné deriváty hepatoprotektivního flavonolignanu silybinu (galaktosid, glukosid, laktosid a maltosid) byly studovány pro svoje vlastnosti lapačů radikálů a snižování míry lipoperoxidace. Ve shodě s výsledky cyklické volumetrie jsou glykosidy silybinu slabšími donory elektronů než aglykon, ale na modelech vychytávání radikálů (metody DPPH a TEAC) byly glykosidy lepšími lapači radikálů než samotný silybin. Glykosidy vykazovaly vyšší ochranu proti terc-butylhydroperoxidem vyvolávanou lipoperoxidaci potkaních jaterních mitochondriálních membrán, dále také lépe chránily proti toxickému účinku terc-butylhydroperoxidu na modelech potkaních erytrocytů a primárních kultur potkaních hepatocytů ve srovnání se silybinem. Glykosilace silybinu snižovala vlastní toxicitu aglykonu, pozorovanou na potkaních hepatocytech při delších intervalech inkubace. Výsledky ukazují, že glykosidy silybinu, rozpustné deriváty silybinu, jsou vhodné pro další studie a mohou mít terapeutický potenciál. (cs)
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| Title
| - Antioxidant properties of silybin glykosides
- Antioxidant properties of silybin glykosides (en)
- Antioxidační vlastnosti silybinových glykosidů (cs)
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| skos:prefLabel
| - Antioxidant properties of silybin glykosides
- Antioxidant properties of silybin glykosides (en)
- Antioxidační vlastnosti silybinových glykosidů (cs)
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| skos:notation
| - RIV/61989592:15110/02:00006953!RIV09-MSM-15110___
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
| - P(GA303/98/0414), Z(MSM 151100003)
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/61989592:15110/02:00006953
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - Silybin glykosides; Radical scavenging; Lipoperoxidation; Rat hepatocytes (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...vavai/riv/projekt
| |
| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Křen, Vladimír
- Kosina, Pavel
- Ulrichová, Jitka
- Walterová, Daniela
- Gebhardt, Rolf
- Grambal, František
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| http://linked.open...n/vavai/riv/zamer
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| issn
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| number of pages
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| http://localhost/t...ganizacniJednotka
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