About: Cell suspensions, cell cultures, and tissue slices - important metabolic in vitro systems

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	In vitro subcellular and cellular systems have important and irreplaceable roles in the metabolic investigations that precede the development of new potential drugs. Of these model systems, tissue slices are probably the nearest to in vivo conditions. From the experimental and complexity points of view, perfused organs lie midway between tisssue slices and whole organism. Preparation and working with liver slices is quick and easy, and, excess material can be cryopreserved and stored untill the next experiment. Slices can be prepared from a wide variety of organs and it is possible to co-incubate them. Another important feature is the possibility of interspecies comparison of slices. Different experiments can be run both in the short-term as well as long-term incubations. Each in vitro system has an important place for example, in the development of new medicaments. It is therefore important to compare and supplement experimental results from different in vitro systems when extrapolating to in In vitro subcellular and cellular systems have important and irreplaceable roles in the metabolic investigations that precede the development of new potential drugs. Of these model systems, tissue slices are probably the nearest to in vivo conditions. From the experimental and complexity points of view, perfused organs lie midway between tisssue slices and whole organism. Preparation and working with liver slices is quick and easy, and, excess material can be cryopreserved and stored untill the next experiment. Slices can be prepared from a wide variety of organs and it is possible to co-incubate them. Another important feature is the possibility of interspecies comparison of slices. Different experiments can be run both in the short-term as well as long-term incubations. Each in vitro system has an important place for example, in the development of new medicaments. It is therefore important to compare and supplement experimental results from different in vitro systems when extrapolating to in (en) In vitro subcelulární a buněčné systémy mají významné a nenahraditelné role v metabolických výzkumech, které předchází vývoji nových potenciálních léků. (cs)
Title	Buněčné suspenze, buněčné kultury a tkáňové řezy - důležité metabolické in vitro systémy (cs) Cell suspensions, cell cultures, and tissue slices - important metabolic in vitro systems Cell suspensions, cell cultures, and tissue slices - important metabolic in vitro systems (en)
skos:prefLabel	Buněčné suspenze, buněčné kultury a tkáňové řezy - důležité metabolické in vitro systémy (cs) Cell suspensions, cell cultures, and tissue slices - important metabolic in vitro systems Cell suspensions, cell cultures, and tissue slices - important metabolic in vitro systems (en)
skos:notation	RIV/61989592:15110/01:00006961!RIV09-MSM-15110___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA303/99/P002), P(OC B17.20), Z(MSM 151100001), Z(MSM 151100003)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2009
http://linked.open...aciTvurceVysledku	Veselý, Jaroslav Chmela, Zdeněk Rypka, Miroslav Belejová, Marie Ulrichová, Jitka Modrianský, Martin
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Palackého v Olomouci / Lékařská fakulta
http://linked.open...dnocenehoVysledku	675025
http://linked.open...ai/riv/idVysledku	RIV/61989592:15110/01:00006961
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	In vitro systems; Tissue slices; Metabolism; Viability tests (en)
http://linked.open.../riv/klicoveSlovo	Metabolism In vitro systems Tissue slices Viability tests
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[12127196C2AF]
http://linked.open...i/riv/nazevZdroje	Biomedical Papers
http://linked.open...in/vavai/riv/obor	FR
http://linked.open...ichTvurcuVysledku	6 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...vavai/riv/projekt	Colchicinoids and 6-benzylaminpurine-type cytokines - their effect on expression of selected isoforms of cytochromes P450 in human liver cell cultures http://linked.opendata.cz/resource/domain/vavai/projekt/OC%20B17.20
http://linked.open...UplatneniVysledku	2001
http://linked.open...v/svazekPeriodika	145
http://linked.open...iv/tvurceVysledku	Ulrichová, Jitka Veselý, Jaroslav Modrianský, Martin Rypka, Miroslav Maurel, Patrick Chmela, Zdeněk Belejová, Marie Červenková, Kateřina
http://linked.open...n/vavai/riv/zamer	http://linked.opendata.cz/resource/domain/vavai/zamer/MSM%20151100001 http://linked.opendata.cz/resource/domain/vavai/zamer/MSM%20151100003
issn	0862-481X
number of pages	4 (xsd:int)
http://localhost/t...ganizacniJednotka	15110

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