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| rdf:type
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| Description
| - Adaptation of the organism to hypoxia has profound effect on multiple tissues including regulation of erythropoiesis, vasculogenesis, a proper regulation of embryogenesis as well as other functions. The elucidation of those congenital or acquired mutations giving rise to disease states affecting physiological systems devoted to oxygen homeostasis provides not only a practical diagnostic and potential therapeutic target, but also allows to identify the essential, non-redundant physiological pathways that may be hitherto unknown. The erythropoietin gene was the first gene expression found to be upregulated by hypoxia; the mechanism of this regulation lead to our current understanding of hypoxia sensing. Thus it is appropriate that the disorders resulting from augmented erythropoiesis are subject of this review.
- Adaptation of the organism to hypoxia has profound effect on multiple tissues including regulation of erythropoiesis, vasculogenesis, a proper regulation of embryogenesis as well as other functions. The elucidation of those congenital or acquired mutations giving rise to disease states affecting physiological systems devoted to oxygen homeostasis provides not only a practical diagnostic and potential therapeutic target, but also allows to identify the essential, non-redundant physiological pathways that may be hitherto unknown. The erythropoietin gene was the first gene expression found to be upregulated by hypoxia; the mechanism of this regulation lead to our current understanding of hypoxia sensing. Thus it is appropriate that the disorders resulting from augmented erythropoiesis are subject of this review. (en)
- Adaptace organizmu k hypoxii má zásadní důsledky pro řadu tkání, včetně regulace erytropoézy, vývoj cévního systému, regulace embryogeneze a jiné funkce. Řada mutací (kongenitálních nebo získaných) vede k chorobám postihujícím fyziologické systémy regulované kyslíkovou homeostázou. Jejich odhalování poskytuje nejen diagnostické a terapeutické cíle, ale umožňuje i identifikovat nepostradatelné fyziologické dráhy, které mohou být dosud neznámé. Erytropoetinový gen byl prvním genem, u kterého se zjistila závislost exprese na hypoxii, a mechanizmus této regulace přispěl k dnešnímu poznání zákonitostí vnímavosti k hypoxii. Objektem této kapitoly jsou choroby z nadprodukce červených krvinek. (cs)
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| Title
| - Lekce k lepšímu pochopení vnímání hypoxie: Získané a vrozené mutace vedoucí k polycytémii (cs)
- Lessons to better understanding of hypoxia sensing: Acquired and congenital mutations resulting in polycythemia
- Lessons to better understanding of hypoxia sensing: Acquired and congenital mutations resulting in polycythemia (en)
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| skos:prefLabel
| - Lekce k lepšímu pochopení vnímání hypoxie: Získané a vrozené mutace vedoucí k polycytémii (cs)
- Lessons to better understanding of hypoxia sensing: Acquired and congenital mutations resulting in polycythemia
- Lessons to better understanding of hypoxia sensing: Acquired and congenital mutations resulting in polycythemia (en)
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| skos:notation
| - RIV/61989592:15110/01:00006290!RIV09-MZ0-15110___
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
| - P(NC6652), Z(MSM 151100001)
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/61989592:15110/01:00006290
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - erythropoiesis; erythropoietin receptor; mutations in polycythemia; hypoxia-inducible factor 1; Chuvash polycythemia (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/mistoVydani
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| http://linked.open...i/riv/nazevZdroje
| - Hypoxia: From Genes to the Bedside (Advances in Experimental Medicine and Biology) 502
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| http://linked.open...in/vavai/riv/obor
| |
| http://linked.open...ichTvurcuVysledku
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| http://linked.open...v/pocetStranKnihy
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...vavai/riv/projekt
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| http://linked.open...UplatneniVysledku
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| http://linked.open...iv/tvurceVysledku
| - Divoký, Vladimír
- Prchal, Josef T.
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| http://linked.open...n/vavai/riv/zamer
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| number of pages
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| http://purl.org/ne...btex#hasPublisher
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| https://schema.org/isbn
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| http://localhost/t...ganizacniJednotka
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