About: A Pretreatment Method for Analysing Albendazole by HPLC in Plant Material

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://link.springer.com/article/10.1007%2Fs11270-013-1646-6/fulltext.html
Description	Albendazole (ALB) belongs to a group of benzimidazoles-classified as antiparasitic pharmaceuticals. Its widespread application results in the presence of this pharmaceutical in natural environment (water and soil). In this paper a suitable pretreatment method was established including sampling, freeze-drying and extraction. Vicia faba was used as model organism. ALB accumulation by plant tissues was observed in hydroponic culture as well as in soil. The range of pharmaceutical concentrations was 1.7 x 10-5 mol/L (in hydroponic culture) and 1.7 x 10-5 to 1.7 x 10-4 mol/kg air dry soil (in soil). Observations were conducted for 14 days. After this time biological material was freeze-dried and after homogenization, dimethyl sulfoxide (DMSO) extraction was performed. The recovery of ALB for the roots was 93 % while for the shoots 86 %. After cleaning, the samples were subjected to further analysis by HPLC system. Phosphate buffer and acetonitrile (50:50) were used as a mobile phase. Drug retention time was 6.3 min. Results obtained in this experiment indicate higher drug accumulation in roots rather than in the hypocotyl part of the plant, cultivated both in soil and in hydroponic culture. Albendazole (ALB) belongs to a group of benzimidazoles-classified as antiparasitic pharmaceuticals. Its widespread application results in the presence of this pharmaceutical in natural environment (water and soil). In this paper a suitable pretreatment method was established including sampling, freeze-drying and extraction. Vicia faba was used as model organism. ALB accumulation by plant tissues was observed in hydroponic culture as well as in soil. The range of pharmaceutical concentrations was 1.7 x 10-5 mol/L (in hydroponic culture) and 1.7 x 10-5 to 1.7 x 10-4 mol/kg air dry soil (in soil). Observations were conducted for 14 days. After this time biological material was freeze-dried and after homogenization, dimethyl sulfoxide (DMSO) extraction was performed. The recovery of ALB for the roots was 93 % while for the shoots 86 %. After cleaning, the samples were subjected to further analysis by HPLC system. Phosphate buffer and acetonitrile (50:50) were used as a mobile phase. Drug retention time was 6.3 min. Results obtained in this experiment indicate higher drug accumulation in roots rather than in the hypocotyl part of the plant, cultivated both in soil and in hydroponic culture. (en)
Title	A Pretreatment Method for Analysing Albendazole by HPLC in Plant Material A Pretreatment Method for Analysing Albendazole by HPLC in Plant Material (en)
skos:prefLabel	A Pretreatment Method for Analysing Albendazole by HPLC in Plant Material A Pretreatment Method for Analysing Albendazole by HPLC in Plant Material (en)
skos:notation	RIV/61989100:27650/13:86086159!RIV14-MSM-27650___
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(EE2.3.30.0016)
http://linked.open...iv/cisloPeriodika	vol 224
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Marciocha, Dorota
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Vysoká škola báňská - Technická univerzita Ostrava / Výzkumné energetické centrum
http://linked.open...dnocenehoVysledku	58959
http://linked.open...ai/riv/idVysledku	RIV/61989100:27650/13:86086159
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Sample preparation; HPLC; Plant; Albendazole (en)
http://linked.open.../riv/klicoveSlovo	Albendazole Plant HPLC Sample preparation
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[EC859AA2A60A]
http://linked.open...i/riv/nazevZdroje	Water, Air, and Soil Pollution
http://linked.open...in/vavai/riv/obor	CC
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Opportunities for young researchers
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	2013
http://linked.open...iv/tvurceVysledku	Kalka, Joanna Marciocha, Dorota Surmacz - Górska, Joanna Turek - Szytow, Jolanta
http://linked.open...ain/vavai/riv/wos	000323255900011
issn	0049-6979
number of pages	8 (xsd:int)
http://bibframe.org/vocab/doi	10.1007/s11270-013-1646-6
http://localhost/t...ganizacniJednotka	27650

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