About: A large number of nuclear genes in the human parasite Blastocystis require mRNA polyadenylation to create functional termination codons

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About: A large number of nuclear genes in the human parasite Blastocystis require mRNA polyadenylation to create functional termination codons Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Termination codons in mRNA molecules are typically specified directly by the sequence of the corresponding gene. However, in mitochondria of a few eukaryotic groups, some mRNAs contain the termination codon UAA deriving one or both adenosines from transcript polyadenylation. Here, we show that a similar phenomenon occurs for a substantial number of nuclear genes in Blastocystis spp., divergent unicellular eukaryote gut parasites. Our analyses of published genomic data from Blastocystis sp. subtype 7 revealed that polyadenylation-mediated creation of termination codons occurs in approximately 15% of all nuclear genes. As this phenomenon has not been noticed before, the procedure previously employed to annotate the Blastocystis nuclear genome sequence failed to correctly define the structure of the 30-ends of hundreds of genes. From sequence data we have obtained from the distantly related Blastocystis sp. subtype 1 strain, we show that this phenomenon is widespread within the Blastocystis genus? Termination codons in mRNA molecules are typically specified directly by the sequence of the corresponding gene. However, in mitochondria of a few eukaryotic groups, some mRNAs contain the termination codon UAA deriving one or both adenosines from transcript polyadenylation. Here, we show that a similar phenomenon occurs for a substantial number of nuclear genes in Blastocystis spp., divergent unicellular eukaryote gut parasites. Our analyses of published genomic data from Blastocystis sp. subtype 7 revealed that polyadenylation-mediated creation of termination codons occurs in approximately 15% of all nuclear genes. As this phenomenon has not been noticed before, the procedure previously employed to annotate the Blastocystis nuclear genome sequence failed to correctly define the structure of the 30-ends of hundreds of genes. From sequence data we have obtained from the distantly related Blastocystis sp. subtype 1 strain, we show that this phenomenon is widespread within the Blastocystis genus? (en)
Title	A large number of nuclear genes in the human parasite Blastocystis require mRNA polyadenylation to create functional termination codons A large number of nuclear genes in the human parasite Blastocystis require mRNA polyadenylation to create functional termination codons (en)
skos:prefLabel	A large number of nuclear genes in the human parasite Blastocystis require mRNA polyadenylation to create functional termination codons A large number of nuclear genes in the human parasite Blastocystis require mRNA polyadenylation to create functional termination codons (en)
skos:notation	RIV/61988987:17310/14:A1501CHD!RIV15-MSM-17310___
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(ED2.1.00/03.0100), P(GA13-33039S), P(LO1208)
http://linked.open...iv/cisloPeriodika	8
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Eliáš, Marek Klimeš, Vladimír
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ostravská univerzita v Ostravě / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	797
http://linked.open...ai/riv/idVysledku	RIV/61988987:17310/14:A1501CHD
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Blastocystis; evolution; gene expression; mRNA processing; polyadenylation; termination codons; translation (en)
http://linked.open.../riv/klicoveSlovo	gene expression evolution translation Blastocystis mRNA processing termination codons polyadenylation
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[365EED5197BE]
http://linked.open...i/riv/nazevZdroje	Genome Biology and Evolution
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Teoretické aspekty energetického zpracování odpadů a ochrany prostředí před negativními dopady Institute of environmental technologies Genomický přístup k odhalování biologie a evoluce eustigmatofytních řas
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	6
http://linked.open...iv/tvurceVysledku	Eliáš, Marek Roger, A. J. Klimeš, Vladimír Gentekaki, E.
http://linked.open...ain/vavai/riv/wos	000342976600004
issn	1759-6653
number of pages	6 (xsd:int)
http://localhost/t...ganizacniJednotka	17310

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