About: Sculpting the endomembrane system in deep time: high resolution phylogenetics of Rab GTPases

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About: Sculpting the endomembrane system in deep time: high resolution phylogenetics of Rab GTPases Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	We have devised and exploited a new phylogenetic strategy to reconstruct the history of the Rab GTPases, a key family of endomembrane-specificity proteins. Strikingly, we infer a remarkably sophisticated organellar composition for the last eukaryotic common ancestor, which we predict possessed as many as 23 Rab GTPases. This repertoire is significantly greater than that present in many modern organisms and indicates a major role for secondary loss in the evolutionary diversification of the endomembrane system. Furthermore, we show that many Rab paralogues emerged relatively suddenly during early metazoan evolution, which is in stark contrast to the lack of significant Rab family expansions at the onset of most other major eukaryotic groups. Finally, we reconstruct higher-order ancestral clades of Rabs primarily linked with endocytic and exocytic process, suggesting the presence of primordial Rabs associated with the establishment of those pathways. We have devised and exploited a new phylogenetic strategy to reconstruct the history of the Rab GTPases, a key family of endomembrane-specificity proteins. Strikingly, we infer a remarkably sophisticated organellar composition for the last eukaryotic common ancestor, which we predict possessed as many as 23 Rab GTPases. This repertoire is significantly greater than that present in many modern organisms and indicates a major role for secondary loss in the evolutionary diversification of the endomembrane system. Furthermore, we show that many Rab paralogues emerged relatively suddenly during early metazoan evolution, which is in stark contrast to the lack of significant Rab family expansions at the onset of most other major eukaryotic groups. Finally, we reconstruct higher-order ancestral clades of Rabs primarily linked with endocytic and exocytic process, suggesting the presence of primordial Rabs associated with the establishment of those pathways. (en)
Title	Sculpting the endomembrane system in deep time: high resolution phylogenetics of Rab GTPases Sculpting the endomembrane system in deep time: high resolution phylogenetics of Rab GTPases (en)
skos:prefLabel	Sculpting the endomembrane system in deep time: high resolution phylogenetics of Rab GTPases Sculpting the endomembrane system in deep time: high resolution phylogenetics of Rab GTPases (en)
skos:notation	RIV/61988987:17310/12:A130176D!RIV13-GA0-17310___
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(GAP305/10/0205)
http://linked.open...iv/cisloPeriodika	Pt 10
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Eliáš, Marek
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ostravská univerzita v Ostravě / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	166916
http://linked.open...ai/riv/idVysledku	RIV/61988987:17310/12:A130176D
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	evolution; membrane traffic; phylogenetics; Rab GTPases (en)
http://linked.open.../riv/klicoveSlovo	evolution Rab GTPases membrane traffic phylogenetics
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[CE06D21FE67F]
http://linked.open...i/riv/nazevZdroje	J CELL SCI
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	The Ras superfamily of GTPases and the evolution of the eukaryotic cell
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	125
http://linked.open...iv/tvurceVysledku	Eliáš, Marek Dacks, Joel B. Brighouse, Andrew Field, Mark C. Gabernet-Castello, Carme
http://linked.open...ain/vavai/riv/wos	000306107000016
issn	0021-9533
number of pages	9 (xsd:int)
http://localhost/t...ganizacniJednotka	17310

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