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rdf:type
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Description
| - Pathogen recognition is often mediated by a wealth of fast-evolving receptors, many of which contain ligand-binding and signal transduction domains, such as leucine-rich or tetratricopeptide repeat (LRR/TPR) and NB-ARC domains, respectively. We mined the genome of the brown alga Ectocarpus siliculosus for homologues of these genes and assessed the evolutionary pressures acting upon them. We thus annotated all Ectocarpus LRR-containing genes, in particular an original group of LRR-containing GTPases of the ROCO family, and 24 NB-ARC-TPR proteins. They exhibit high birth and death rates, while a diversifying selection is acting on their LRR (respectively TPR) domain, probably affecting the ligand-binding specificities. Remarkably, each repeat is encoded by an exon, and the intense exon shuffling underpins the variability of LRR and TPR domains. The Ectocarpus ROCO and NB-ARC-TPR families are thus excellent candidates for being involved in recognition/transduction events linked to immunity.
- Pathogen recognition is often mediated by a wealth of fast-evolving receptors, many of which contain ligand-binding and signal transduction domains, such as leucine-rich or tetratricopeptide repeat (LRR/TPR) and NB-ARC domains, respectively. We mined the genome of the brown alga Ectocarpus siliculosus for homologues of these genes and assessed the evolutionary pressures acting upon them. We thus annotated all Ectocarpus LRR-containing genes, in particular an original group of LRR-containing GTPases of the ROCO family, and 24 NB-ARC-TPR proteins. They exhibit high birth and death rates, while a diversifying selection is acting on their LRR (respectively TPR) domain, probably affecting the ligand-binding specificities. Remarkably, each repeat is encoded by an exon, and the intense exon shuffling underpins the variability of LRR and TPR domains. The Ectocarpus ROCO and NB-ARC-TPR families are thus excellent candidates for being involved in recognition/transduction events linked to immunity. (en)
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Title
| - Highly Dynamic Exon Shuffling in Candidate Pathogen Receptors ? What if Brown Algae Were Capable of Adaptive Immunity?
- Highly Dynamic Exon Shuffling in Candidate Pathogen Receptors ? What if Brown Algae Were Capable of Adaptive Immunity? (en)
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skos:prefLabel
| - Highly Dynamic Exon Shuffling in Candidate Pathogen Receptors ? What if Brown Algae Were Capable of Adaptive Immunity?
- Highly Dynamic Exon Shuffling in Candidate Pathogen Receptors ? What if Brown Algae Were Capable of Adaptive Immunity? (en)
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skos:notation
| - RIV/61988987:17310/12:A130176A!RIV13-GA0-17310___
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/61988987:17310/12:A130176A
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - brown alga; Ectocarpus; exon shuffling; resistance gene analogue; innate immunity; adaptive immunity (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
| - GB - Spojené království Velké Británie a Severního Irska
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...vavai/riv/projekt
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Eliáš, Marek
- Gachon, Claire M. M.
- Maumus, Florian
- Sterck, Lieven
- Zambounis, Antonios
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http://linked.open...ain/vavai/riv/wos
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issn
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number of pages
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http://localhost/t...ganizacniJednotka
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