About: Rho GTPases: deciphering the evolutionary history of a complex protein family

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Rho GTPases: deciphering the evolutionary history of a complex protein family Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	We ruminate on several aspects of the evolutionary history of the Rho family and methodical challenges of its reconstruction. First, we provide an updated survey of Rho GTPases in diverse eukaryotic branches, demonstrating almost ubiquitous occurrence of Rho genes across the eukaryotic phylogeny most consistent with the presence of at least one Rho gene already in the last eukaryotic common ancestor. Second, we discuss the obstacles in reconstructing the history of gene duplications giving rise to the extant diversity of Rho paralogs in different species, and point to numerous limitations posed by the current phylogenetic methodology. Third, as a case study demonstrating various issues of data collection, phylogenetic analyses and interpretations of trees, we present an analysis of the Rho family in the fungal kingdom, revealing the existence of at least four separate paralogs in early fungi and subsequent potentially independent expansions of the family in different fungal subgroups. We ruminate on several aspects of the evolutionary history of the Rho family and methodical challenges of its reconstruction. First, we provide an updated survey of Rho GTPases in diverse eukaryotic branches, demonstrating almost ubiquitous occurrence of Rho genes across the eukaryotic phylogeny most consistent with the presence of at least one Rho gene already in the last eukaryotic common ancestor. Second, we discuss the obstacles in reconstructing the history of gene duplications giving rise to the extant diversity of Rho paralogs in different species, and point to numerous limitations posed by the current phylogenetic methodology. Third, as a case study demonstrating various issues of data collection, phylogenetic analyses and interpretations of trees, we present an analysis of the Rho family in the fungal kingdom, revealing the existence of at least four separate paralogs in early fungi and subsequent potentially independent expansions of the family in different fungal subgroups. (en)
Title	Rho GTPases: deciphering the evolutionary history of a complex protein family Rho GTPases: deciphering the evolutionary history of a complex protein family (en)
skos:prefLabel	Rho GTPases: deciphering the evolutionary history of a complex protein family Rho GTPases: deciphering the evolutionary history of a complex protein family (en)
skos:notation	RIV/61988987:17310/12:A1301768!RIV13-GA0-17310___
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(GAP305/10/0205)
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Eliáš, Marek Klimeš, Vladimír
http://linked.open.../riv/druhVysledku	C - Kapitola v knize
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ostravská univerzita v Ostravě / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	165550
http://linked.open...ai/riv/idVysledku	RIV/61988987:17310/12:A1301768
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Rho GTPases; phylogeny; evolution; eukaryotic cell; fungi (en)
http://linked.open.../riv/klicoveSlovo	fungi evolution phylogeny eukaryotic cell Rho GTPases
http://linked.open...ontrolniKodProRIV	[37F35D18D4BA]
http://linked.open...vEdiceCisloSvazku	Methods in Molecular Biology 827
http://linked.open...i/riv/nazevZdroje	Rho GTPases. Methods and Protocols.
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...v/pocetStranKnihy	407 (xsd:int)
http://linked.open...cetTvurcuVysledku	2 (xsd:int)
http://linked.open...vavai/riv/projekt	The Ras superfamily of GTPases and the evolution of the eukaryotic cell
http://linked.open...UplatneniVysledku	2012
http://linked.open...iv/tvurceVysledku	Eliáš, Marek Klimeš, Vladimír
number of pages	22 (xsd:int)
http://purl.org/ne...btex#hasPublisher	Humana Press
https://schema.org/isbn	978-1-61779-441-4
http://localhost/t...ganizacniJednotka	17310

Faceted Search & Find service v1.16.118 as of Jun 21 2024

Alternative Linked Data Documents: ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 58 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software