About: The Ras related GTPase Miro is not required for mitochondrial transport in Dictyostelium discoideum     Goto   Sponge   NotDistinct   Permalink

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  • We disrupted the single Miro-encoding gene in Dictyostelium discoideum and observed a substantial growth defect that we attribute to a decreased mitochondrial mass and cellular ATP content. However, mutant cells even showed an increased rate of oxygen consumption, while glucose consumption, mitochondrial transmembrane potential and production of reactive oxygen species were unaltered. Processes characteristic of the multicellular stage of the D. discoideum life cycle were also unaltered. Although mitochondria occasionally use microtubules for transport in D. discoideum, their size and distribution were not visibly affected. We found Miro in all branches of the eukaryotic tree with the exception of a few protist lineages (mainly those lacking typical mitochondria). We propose that in D. discoideum Miro plays roles in mitochondrial homeostasis, but the ability to build a complex that regulates its association to kinesin for microtubule-dependent transport probably arose in metazoans.
  • We disrupted the single Miro-encoding gene in Dictyostelium discoideum and observed a substantial growth defect that we attribute to a decreased mitochondrial mass and cellular ATP content. However, mutant cells even showed an increased rate of oxygen consumption, while glucose consumption, mitochondrial transmembrane potential and production of reactive oxygen species were unaltered. Processes characteristic of the multicellular stage of the D. discoideum life cycle were also unaltered. Although mitochondria occasionally use microtubules for transport in D. discoideum, their size and distribution were not visibly affected. We found Miro in all branches of the eukaryotic tree with the exception of a few protist lineages (mainly those lacking typical mitochondria). We propose that in D. discoideum Miro plays roles in mitochondrial homeostasis, but the ability to build a complex that regulates its association to kinesin for microtubule-dependent transport probably arose in metazoans. (en)
Title
  • The Ras related GTPase Miro is not required for mitochondrial transport in Dictyostelium discoideum
  • The Ras related GTPase Miro is not required for mitochondrial transport in Dictyostelium discoideum (en)
skos:prefLabel
  • The Ras related GTPase Miro is not required for mitochondrial transport in Dictyostelium discoideum
  • The Ras related GTPase Miro is not required for mitochondrial transport in Dictyostelium discoideum (en)
skos:notation
  • RIV/61988987:17310/11:A1201431!RIV12-GA0-17310___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(GAP305/10/0205)
http://linked.open...iv/cisloPeriodika
  • 4
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 225722
http://linked.open...ai/riv/idVysledku
  • RIV/61988987:17310/11:A1201431
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • Miro; Mitochondrial transport; Small GTPase; Dictyostelium (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • DE - Spolková republika Německo
http://linked.open...ontrolniKodProRIV
  • [115731642B21]
http://linked.open...i/riv/nazevZdroje
  • EUR J CELL BIOL
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 90
http://linked.open...iv/tvurceVysledku
  • Eliáš, Marek
  • Rivero, Francisco
  • Vlahou, Georgia
  • Wiesner, Rudolf J.
  • von Kleist-Retzow, Jürgen-Christoph
http://linked.open...ain/vavai/riv/wos
  • 000289387400007
issn
  • 0171-9335
number of pages
http://localhost/t...ganizacniJednotka
  • 17310
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