About: Comparison of metoprolol/-hydroxymetoprolol metabolic ratio after a single dose and in steady state     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
Description
  • Metoprolol/alfa-hydroxymetoprolol metabolic ratio (MR) 3 hours after a single metoprolol dose is used for cytochrome P450 2D6 phenotyping. The aim was to compare cytochrome P450 2D6 metabolic activity after the first metoprolol dose and in steady state. Thirteen adult hypertinsive patients (7 females) in whom an antroduction of the beta-blocker metoprolol was indicated were included. Age (mean ? SD) was 42,8 ? 12,9 years, weight (mean ? SD) was 94,0 ? 25,4 kg. Metoprolol dose was chosen based on clinical grounds on the day of metoprolol first ingestion. Blood samples were drawn after the first dose and at least 2 weeks since metoprolol introduction to ensure steady state. The patients were phenotyped as extensive metabolizers in both periods, after metoprolol first ingestion and in steady state. We observed a significant correlation (rs = 0,8418, P = 0,0003) between the metoprolol/alfa-hydroxymetoprolol MRs.
  • Metoprolol/alfa-hydroxymetoprolol metabolic ratio (MR) 3 hours after a single metoprolol dose is used for cytochrome P450 2D6 phenotyping. The aim was to compare cytochrome P450 2D6 metabolic activity after the first metoprolol dose and in steady state. Thirteen adult hypertinsive patients (7 females) in whom an antroduction of the beta-blocker metoprolol was indicated were included. Age (mean ? SD) was 42,8 ? 12,9 years, weight (mean ? SD) was 94,0 ? 25,4 kg. Metoprolol dose was chosen based on clinical grounds on the day of metoprolol first ingestion. Blood samples were drawn after the first dose and at least 2 weeks since metoprolol introduction to ensure steady state. The patients were phenotyped as extensive metabolizers in both periods, after metoprolol first ingestion and in steady state. We observed a significant correlation (rs = 0,8418, P = 0,0003) between the metoprolol/alfa-hydroxymetoprolol MRs. (en)
Title
  • Comparison of metoprolol/-hydroxymetoprolol metabolic ratio after a single dose and in steady state
  • Comparison of metoprolol/-hydroxymetoprolol metabolic ratio after a single dose and in steady state (en)
skos:prefLabel
  • Comparison of metoprolol/-hydroxymetoprolol metabolic ratio after a single dose and in steady state
  • Comparison of metoprolol/-hydroxymetoprolol metabolic ratio after a single dose and in steady state (en)
skos:notation
  • RIV/61988987:17110/10:A110109A!RIV11-MSM-17110___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • S
http://linked.open...iv/cisloPeriodika
  • 59
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 251479
http://linked.open...ai/riv/idVysledku
  • RIV/61988987:17110/10:A110109A
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • cytochrome P450 2D6 - phenotype; probe drug; metoprolol (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • CZ - Česká republika
http://linked.open...ontrolniKodProRIV
  • [39AAF2E99B18]
http://linked.open...i/riv/nazevZdroje
  • česká a slovenská farmacie
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 5
http://linked.open...iv/tvurceVysledku
  • Grundmann, Milan
  • Peřinová, Ilona
  • Kacířová, Ivana
  • Ďuricová, J.
issn
  • 1210-7816
number of pages
http://localhost/t...ganizacniJednotka
  • 17110
Faceted Search & Find service v1.16.118 as of Jun 21 2024


Alternative Linked Data Documents: ODE     Content Formats:   [cxml] [csv]     RDF   [text] [turtle] [ld+json] [rdf+json] [rdf+xml]     ODATA   [atom+xml] [odata+json]     Microdata   [microdata+json] [html]    About   
This material is Open Knowledge   W3C Semantic Web Technology [RDF Data] Valid XHTML + RDFa
OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 41 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software