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rdf:type
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Description
| - The effects of the probiotic bacteria Enterococcus faecium (EF) and selenium were studied on methotrexate (MTX) treatment in rats with adjuvant arthritis. Arthritic rats were treated orally with the following substances: lyophilized EF (15 mg/kg/day, 5 days a week), sodium selenite pentahydrate (SSe; 0.050 mg(kg containing 0.015 mg/kg selenium, 5 days a week), MTX (0.6 mg/kg/week), a their combinations for the period of 50 days from adjuvant application. Levels of serum albumin, serum nitrite/nitrate concentrations, hind paw swelling, arthrogram scores, whole-body bone mineral density (BMD), and bone erosions were evaluated as markers of inflammation and destructive changes associated with arthritis. Long-term preventive treatment with low-dose MTX significantly inhibited the markers of the inflammation and arthritis. Our results indicate that EF may increase the preventive effect of MTX treatment in rat adjuvant arthritis by improving its anti-inflammatory and antiarthritic effects.
- The effects of the probiotic bacteria Enterococcus faecium (EF) and selenium were studied on methotrexate (MTX) treatment in rats with adjuvant arthritis. Arthritic rats were treated orally with the following substances: lyophilized EF (15 mg/kg/day, 5 days a week), sodium selenite pentahydrate (SSe; 0.050 mg(kg containing 0.015 mg/kg selenium, 5 days a week), MTX (0.6 mg/kg/week), a their combinations for the period of 50 days from adjuvant application. Levels of serum albumin, serum nitrite/nitrate concentrations, hind paw swelling, arthrogram scores, whole-body bone mineral density (BMD), and bone erosions were evaluated as markers of inflammation and destructive changes associated with arthritis. Long-term preventive treatment with low-dose MTX significantly inhibited the markers of the inflammation and arthritis. Our results indicate that EF may increase the preventive effect of MTX treatment in rat adjuvant arthritis by improving its anti-inflammatory and antiarthritic effects. (en)
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Title
| - Combination treatment of rat adjuvant-induced arthritis with methotrexate, probitic bacteria Enterococcus faecium and selenium
- Combination treatment of rat adjuvant-induced arthritis with methotrexate, probitic bacteria Enterococcus faecium and selenium (en)
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skos:prefLabel
| - Combination treatment of rat adjuvant-induced arthritis with methotrexate, probitic bacteria Enterococcus faecium and selenium
- Combination treatment of rat adjuvant-induced arthritis with methotrexate, probitic bacteria Enterococcus faecium and selenium (en)
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skos:notation
| - RIV/61988987:17110/05:A1100UBA!RIV11-MSM-17110___
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/61988987:17110/05:A1100UBA
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - Adjuvant arthritis; Enterococcus faecium; methotrexate; selenium (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...UplatneniVysledku
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http://linked.open...iv/tvurceVysledku
| - Kamarád, Vojtěch
- Rovenský, J.
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http://linked.open...ain/vavai/riv/wos
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issn
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number of pages
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http://localhost/t...ganizacniJednotka
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