About: Combination treatment of rat adjuvant-induced arthritis with methotrexate, probitic bacteria Enterococcus faecium and selenium

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About: Combination treatment of rat adjuvant-induced arthritis with methotrexate, probitic bacteria Enterococcus faecium and selenium Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The effects of the probiotic bacteria Enterococcus faecium (EF) and selenium were studied on methotrexate (MTX) treatment in rats with adjuvant arthritis. Arthritic rats were treated orally with the following substances: lyophilized EF (15 mg/kg/day, 5 days a week), sodium selenite pentahydrate (SSe; 0.050 mg(kg containing 0.015 mg/kg selenium, 5 days a week), MTX (0.6 mg/kg/week), a their combinations for the period of 50 days from adjuvant application. Levels of serum albumin, serum nitrite/nitrate concentrations, hind paw swelling, arthrogram scores, whole-body bone mineral density (BMD), and bone erosions were evaluated as markers of inflammation and destructive changes associated with arthritis. Long-term preventive treatment with low-dose MTX significantly inhibited the markers of the inflammation and arthritis. Our results indicate that EF may increase the preventive effect of MTX treatment in rat adjuvant arthritis by improving its anti-inflammatory and antiarthritic effects. The effects of the probiotic bacteria Enterococcus faecium (EF) and selenium were studied on methotrexate (MTX) treatment in rats with adjuvant arthritis. Arthritic rats were treated orally with the following substances: lyophilized EF (15 mg/kg/day, 5 days a week), sodium selenite pentahydrate (SSe; 0.050 mg(kg containing 0.015 mg/kg selenium, 5 days a week), MTX (0.6 mg/kg/week), a their combinations for the period of 50 days from adjuvant application. Levels of serum albumin, serum nitrite/nitrate concentrations, hind paw swelling, arthrogram scores, whole-body bone mineral density (BMD), and bone erosions were evaluated as markers of inflammation and destructive changes associated with arthritis. Long-term preventive treatment with low-dose MTX significantly inhibited the markers of the inflammation and arthritis. Our results indicate that EF may increase the preventive effect of MTX treatment in rat adjuvant arthritis by improving its anti-inflammatory and antiarthritic effects. (en)
Title	Combination treatment of rat adjuvant-induced arthritis with methotrexate, probitic bacteria Enterococcus faecium and selenium Combination treatment of rat adjuvant-induced arthritis with methotrexate, probitic bacteria Enterococcus faecium and selenium (en)
skos:prefLabel	Combination treatment of rat adjuvant-induced arthritis with methotrexate, probitic bacteria Enterococcus faecium and selenium Combination treatment of rat adjuvant-induced arthritis with methotrexate, probitic bacteria Enterococcus faecium and selenium (en)
skos:notation	RIV/61988987:17110/05:A1100UBA!RIV11-MSM-17110___
http://linked.open...avai/riv/aktivita	V
http://linked.open...avai/riv/aktivity	V
http://linked.open...iv/cisloPeriodika	1051
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Kamarád, Vojtěch
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ostravská univerzita v Ostravě / Lékařská fakulta
http://linked.open...dnocenehoVysledku	515696
http://linked.open...ai/riv/idVysledku	RIV/61988987:17110/05:A1100UBA
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Adjuvant arthritis; Enterococcus faecium; methotrexate; selenium (en)
http://linked.open.../riv/klicoveSlovo	Adjuvant arthritis Enterococcus faecium selenium methotrexate
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[DD6EEB4B04DD]
http://linked.open...i/riv/nazevZdroje	ANN NY ACAD SCI
http://linked.open...in/vavai/riv/obor	FP
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	2 (xsd:int)
http://linked.open...UplatneniVysledku	2005
http://linked.open...iv/tvurceVysledku	Kamarád, Vojtěch Rovenský, J.
http://linked.open...ain/vavai/riv/wos	000233393100059
issn	0077-8923
number of pages	12 (xsd:int)
http://localhost/t...ganizacniJednotka	17110

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