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  • The aim of this study was a contemporaneous measurement and a mutual comparison of plasma cells proliferative activity and grade of apoptosis in patients with monoclonal gammopathy of undetermined significance (MGUS) and various phases of MM i.e. smoldering (SMM), stable/plateau and active (progression/relapse) forms of this disease. The analyzed group of 197 patients consisted of 30 MGUS, 21 SMM, 82 patients examined at the time of MM diagnosis and 64 patients analyzed during various phases of the disease after previous chemotherapy. Plasma cell proliferative activity was measured by means of a propidium iodide index (PC-PI) examined by flow cytometry using a DNA/CD138 double staining technique. For detection of plasma cells entering apoptosis (PC-AI) flow cytometry method with annexin. V FITC and MoAb CD138 was used.
  • The aim of this study was a contemporaneous measurement and a mutual comparison of plasma cells proliferative activity and grade of apoptosis in patients with monoclonal gammopathy of undetermined significance (MGUS) and various phases of MM i.e. smoldering (SMM), stable/plateau and active (progression/relapse) forms of this disease. The analyzed group of 197 patients consisted of 30 MGUS, 21 SMM, 82 patients examined at the time of MM diagnosis and 64 patients analyzed during various phases of the disease after previous chemotherapy. Plasma cell proliferative activity was measured by means of a propidium iodide index (PC-PI) examined by flow cytometry using a DNA/CD138 double staining technique. For detection of plasma cells entering apoptosis (PC-AI) flow cytometry method with annexin. V FITC and MoAb CD138 was used. (en)
Title
  • A contribution to examination of propidium iodide and annexin V plasma cells indices in multiple myeloma
  • A contribution to examination of propidium iodide and annexin V plasma cells indices in multiple myeloma (en)
skos:prefLabel
  • A contribution to examination of propidium iodide and annexin V plasma cells indices in multiple myeloma
  • A contribution to examination of propidium iodide and annexin V plasma cells indices in multiple myeloma (en)
skos:notation
  • RIV/61988987:17110/03:A1000VRL!RIV10-MSM-17110___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • S
http://linked.open...iv/cisloPeriodika
  • 5
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 596844
http://linked.open...ai/riv/idVysledku
  • RIV/61988987:17110/03:A1000VRL
http://linked.open...riv/jazykVysledku
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  • multiple myeloma; plasma cell; propidium iodide index; annexin V index; proliferation; apoptosis (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • SK - Slovenská republika
http://linked.open...ontrolniKodProRIV
  • [1B0A8E3F7015]
http://linked.open...i/riv/nazevZdroje
  • NEOPLASMA
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http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 50
http://linked.open...iv/tvurceVysledku
  • Martínek, Arnošt
http://linked.open...ain/vavai/riv/wos
  • 000186334800009
issn
  • 0028-2685
number of pages
http://localhost/t...ganizacniJednotka
  • 17110
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