About: Synthesis of Lupane-Type Saponins Containing an Unusual alpha-D-Idopyranoside Fragment as Potent Cytotoxic Agents

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About: Synthesis of Lupane-Type Saponins Containing an Unusual alpha-D-Idopyranoside Fragment as Potent Cytotoxic Agents Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	A practical method for the preparation of benzoyl protected allyl and benzyl alpha-D-idopyranosides, and D-idopyranosyl trichloroacetimidate, from 1,2,3,4,6-penta-O-acetyl-alpha-D-idopyranose, is described. All derivatives can be prepared on a multigram scale and require only simple chromatographic purification. A concise synthesis of lupane triterpenes bearing an unusual D-idopyranoside fragment is described. All new compounds were evaluated in vitro for their cytotoxic activities. Novel saponins exhibited interesting cytotoxic activity in the micromolar range against human cancer cell lines including T-lymphoblastic leukemia CEM, breast adenocarcinoma MCF7, and cervical carcinoma HeLa, but also against normal human fibroblasts BJ. A practical method for the preparation of benzoyl protected allyl and benzyl alpha-D-idopyranosides, and D-idopyranosyl trichloroacetimidate, from 1,2,3,4,6-penta-O-acetyl-alpha-D-idopyranose, is described. All derivatives can be prepared on a multigram scale and require only simple chromatographic purification. A concise synthesis of lupane triterpenes bearing an unusual D-idopyranoside fragment is described. All new compounds were evaluated in vitro for their cytotoxic activities. Novel saponins exhibited interesting cytotoxic activity in the micromolar range against human cancer cell lines including T-lymphoblastic leukemia CEM, breast adenocarcinoma MCF7, and cervical carcinoma HeLa, but also against normal human fibroblasts BJ. (en)
Title	Synthesis of Lupane-Type Saponins Containing an Unusual alpha-D-Idopyranoside Fragment as Potent Cytotoxic Agents Synthesis of Lupane-Type Saponins Containing an Unusual alpha-D-Idopyranoside Fragment as Potent Cytotoxic Agents (en)
skos:prefLabel	Synthesis of Lupane-Type Saponins Containing an Unusual alpha-D-Idopyranoside Fragment as Potent Cytotoxic Agents Synthesis of Lupane-Type Saponins Containing an Unusual alpha-D-Idopyranoside Fragment as Potent Cytotoxic Agents (en)
skos:notation	RIV/61389030:_____/14:00433374!RIV15-GA0-61389030
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(GA14-19590S), P(LO1204)
http://linked.open...iv/cisloPeriodika	19
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Strnad, Miroslav Rárová, Lucie Oklešťková, Jana
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav experimentální botaniky AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	49037
http://linked.open...ai/riv/idVysledku	RIV/61389030:_____/14:00433374
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Carbohydrates; Glycoconjugates; Glycosylation (en)
http://linked.open.../riv/klicoveSlovo	Carbohydrates Glycosylation Glycoconjugates
http://linked.open...odStatuVydavatele	DE - Spolková republika Německo
http://linked.open...ontrolniKodProRIV	[7BB493BD088E]
http://linked.open...i/riv/nazevZdroje	European Journal of Organic Chemistry
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...vavai/riv/projekt	Udržitelný rozvoj výzkumu v Centru regionu Haná Modulation od cyclin-dependent kinases in haematological malignancies
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	JUL 2014
http://linked.open...iv/tvurceVysledku	Strnad, Miroslav Rárová, Lucie Oklešťková, Jana Cmoch, P. Gwardiak, K. Karczewski, R. Korda, A. Pakulski, Z.
http://linked.open...ain/vavai/riv/wos	000338018400017
issn	1434-193X
number of pages	10 (xsd:int)
http://bibframe.org/vocab/doi	10.1002/ejoc.201402187

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