About: Substituted 2-hydroxy-N-(arylalkyl)benzamides induce apoptosis in cancer cell lines

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Variously substituted 2-hydroxy-N-(arylallcyl)benzamides were prepared and screened for anti-proliferative and cytotoxic activity in cancer cell lines in vitro. Five compounds, out of 33 showed single-digit micromolar IC50 values against several human cancer cell lines. One of the most potent compounds N-((R)-1-(4-chlorophenylcarbamoyl)-2-phenylethyl)-5-chloro-2-hydroxybenzamide (6k) reduced proliferation and induced apoptosis in the melanoma cell line G361 in a dose-dependent manner, as shown by decrease in 5-bromo-2'-deoxyuridine incorporation and increase in several apoptotic markers, including subdiploid population increase, activation of caspases and site-specific poly-(ADP-ribose)polymerase (PARP) cleavage. Variously substituted 2-hydroxy-N-(arylallcyl)benzamides were prepared and screened for anti-proliferative and cytotoxic activity in cancer cell lines in vitro. Five compounds, out of 33 showed single-digit micromolar IC50 values against several human cancer cell lines. One of the most potent compounds N-((R)-1-(4-chlorophenylcarbamoyl)-2-phenylethyl)-5-chloro-2-hydroxybenzamide (6k) reduced proliferation and induced apoptosis in the melanoma cell line G361 in a dose-dependent manner, as shown by decrease in 5-bromo-2'-deoxyuridine incorporation and increase in several apoptotic markers, including subdiploid population increase, activation of caspases and site-specific poly-(ADP-ribose)polymerase (PARP) cleavage. (en)
Title	Substituted 2-hydroxy-N-(arylalkyl)benzamides induce apoptosis in cancer cell lines Substituted 2-hydroxy-N-(arylalkyl)benzamides induce apoptosis in cancer cell lines (en)
skos:prefLabel	Substituted 2-hydroxy-N-(arylalkyl)benzamides induce apoptosis in cancer cell lines Substituted 2-hydroxy-N-(arylalkyl)benzamides induce apoptosis in cancer cell lines (en)
skos:notation	RIV/61389030:_____/13:00423094!RIV14-GA0-61389030
http://linked.open...avai/riv/aktivita	P S Z
http://linked.open...avai/riv/aktivity	P(ED2.1.00/03.0101), P(GA301/08/1649), P(GAP305/12/0783), S, Z(AV0Z50380511)
http://linked.open...iv/cisloPeriodika	2013
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Jorda, Radek Kryštof, Vladimír Řezníčková, Eva
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav experimentální botaniky AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	108907
http://linked.open...ai/riv/idVysledku	RIV/61389030:_____/13:00423094
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Diamides; Apoptosis; Cytotoxicity (en)
http://linked.open.../riv/klicoveSlovo	Diamides Apoptosis Cytotoxicity
http://linked.open...odStatuVydavatele	FR - Francouzská republika
http://linked.open...ontrolniKodProRIV	[477C1D723230]
http://linked.open...i/riv/nazevZdroje	European Journal of Medicinal Chemistry
http://linked.open...in/vavai/riv/obor	CE
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	Regional Centre for Applied Molecular Oncology (RECAMO) Evaluation of cyclin-dependent kinase inhibitors in cancer cell lines with specific genetic alterations Modulation of cell division of normal and cancer cells by cyclin-dependent kinase inhibitors
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	68
http://linked.open...iv/tvurceVysledku	Dušek, J. Jorda, Radek Kryštof, Vladimír Hanousek, J. Řezníčková, Eva Imramovský, A. Pauk, K.
http://linked.open...ain/vavai/riv/wos	000326902300027
http://linked.open...n/vavai/riv/zamer	Mechanismy regulace růstu a vývoje rostlin na úrovni buněk, orgánů a celých organismů: fyziologické, genetické a molekulárně biologické základy
issn	0223-5234
number of pages	7 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.ejmech.2013.08.009

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