About: Synthesis and Biological Activity of 22-Deoxo-23-oxa Analogues of Saponin OSW-1

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About: Synthesis and Biological Activity of 22-Deoxo-23-oxa Analogues of Saponin OSW-1 Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Analogues of the potent cytotoxic saponin OSW-1 were prepared from the readily available steroidal 16 beta,17 alpha,22-triol. The new 22-deoxo-23-oxa analogues of OSW-1 were screened against eight cancer cell lines and normal human fibroblasts. The analogues proved to be slightly less active than OSW-1 but also less toxic to normal cells. They induce concentration- and time-dependent apoptosis of mammalian cancer cells with caspase-3 activation. Analogues of the potent cytotoxic saponin OSW-1 were prepared from the readily available steroidal 16 beta,17 alpha,22-triol. The new 22-deoxo-23-oxa analogues of OSW-1 were screened against eight cancer cell lines and normal human fibroblasts. The analogues proved to be slightly less active than OSW-1 but also less toxic to normal cells. They induce concentration- and time-dependent apoptosis of mammalian cancer cells with caspase-3 activation. (en)
Title	Synthesis and Biological Activity of 22-Deoxo-23-oxa Analogues of Saponin OSW-1 Synthesis and Biological Activity of 22-Deoxo-23-oxa Analogues of Saponin OSW-1 (en)
skos:prefLabel	Synthesis and Biological Activity of 22-Deoxo-23-oxa Analogues of Saponin OSW-1 Synthesis and Biological Activity of 22-Deoxo-23-oxa Analogues of Saponin OSW-1 (en)
skos:notation	RIV/61389030:_____/11:00368598!RIV12-AV0-61389030
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(ED0007/01/01), P(GA301/08/1649), Z(AV0Z50380511), Z(MSM6198959216)
http://linked.open...iv/cisloPeriodika	9
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Strnad, Miroslav Rárová, Lucie Oklešťková, Jana
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav experimentální botaniky AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	233852
http://linked.open...ai/riv/idVysledku	RIV/61389030:_____/11:00368598
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	POTENT ANTITUMOR SAPONIN; CHOLESTANE GLYCOSIDES; ORNITHOGALUM-SAUNDERSIAE; SIDE-CHAINS; AGLYCONE (en)
http://linked.open.../riv/klicoveSlovo	AGLYCONE CHOLESTANE GLYCOSIDES ORNITHOGALUM-SAUNDERSIAE POTENT ANTITUMOR SAPONIN SIDE-CHAINS
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[CBD2C97632B2]
http://linked.open...i/riv/nazevZdroje	Journal of Medicinal Chemistry
http://linked.open...in/vavai/riv/obor	EF
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	Centre of the Region Haná for Biotechnological and Agricultural Research Modulation of cell division of normal and cancer cells by cyclin-dependent kinase inhibitors
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	54
http://linked.open...iv/tvurceVysledku	Strnad, Miroslav Rárová, Lucie Oklešťková, Jana Maj, J. Morzycki, J. W. Wojtkielewicz, A.
http://linked.open...ain/vavai/riv/wos	000290126800014
http://linked.open...n/vavai/riv/zamer	Mechanismy regulace růstu a vývoje rostlin na úrovni buněk, orgánů a celých organismů: fyziologické, genetické a molekulárně biologické základy Modulation of signalling and regulatory pathways in normal and cancer cells
issn	0022-2623
number of pages	8 (xsd:int)
http://bibframe.org/vocab/doi	10.1021/jm101648h

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