About: Natural Compound Cudraflavone B Shows Promising Anti-inflammatory Properties in Vitro

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Cudraflavone B (1) is a prenylated flavonoid found in large amounts in the roots of Morus alba, a plant used as a herbal remedy for its reputed anti-inflammatory properties. The present study shows that this compound causes a significant inhibition of inflammatory mediators in selected in vitro models: Thus, 1 was identified as a potent inhibitor of tumor necrosis factor a (TNF alpha) gene expression and secretion by blocking the translocation of nuclear factor kappa B (NF-kappa B) from the cytoplasm to the nucleus in macrophages derived from a THP-1 human monocyte cell line. The NF-kappa B activity reduction resulted in the inhibition of cyclooxygenase 2 (COX-2) gene expression. Compound acts as a COX-2 and COX-1 inhibitor with higher selectivity toward COX-2 than indomethacin. This natural product has noticeable anti-inflammatory properties suggesting that 1 potentially could be Used for development as a nonsteroidal anti inflammatory drug lead. Cudraflavone B (1) is a prenylated flavonoid found in large amounts in the roots of Morus alba, a plant used as a herbal remedy for its reputed anti-inflammatory properties. The present study shows that this compound causes a significant inhibition of inflammatory mediators in selected in vitro models: Thus, 1 was identified as a potent inhibitor of tumor necrosis factor a (TNF alpha) gene expression and secretion by blocking the translocation of nuclear factor kappa B (NF-kappa B) from the cytoplasm to the nucleus in macrophages derived from a THP-1 human monocyte cell line. The NF-kappa B activity reduction resulted in the inhibition of cyclooxygenase 2 (COX-2) gene expression. Compound acts as a COX-2 and COX-1 inhibitor with higher selectivity toward COX-2 than indomethacin. This natural product has noticeable anti-inflammatory properties suggesting that 1 potentially could be Used for development as a nonsteroidal anti inflammatory drug lead. (en)
Title	Natural Compound Cudraflavone B Shows Promising Anti-inflammatory Properties in Vitro Natural Compound Cudraflavone B Shows Promising Anti-inflammatory Properties in Vitro (en)
skos:prefLabel	Natural Compound Cudraflavone B Shows Promising Anti-inflammatory Properties in Vitro Natural Compound Cudraflavone B Shows Promising Anti-inflammatory Properties in Vitro (en)
skos:notation	RIV/61389030:_____/11:00367668!RIV12-AV0-61389030
http://linked.open...avai/riv/aktivita	I P S Z
http://linked.open...avai/riv/aktivity	I, P(GP525/09/P528), P(LC06030), S, Z(AV0Z50380511), Z(MSM0021622413)
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Landa, Přemysl Kutil, Zsófia
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav experimentální botaniky AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	215015
http://linked.open...ai/riv/idVysledku	RIV/61389030:_____/11:00367668
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	NF-KAPPA-B; CUDRANIA-TRICUSPIDATA; ROOT BARK (en)
http://linked.open.../riv/klicoveSlovo	CUDRANIA-TRICUSPIDATA NF-KAPPA-B ROOT BARK
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[D64A10010577]
http://linked.open...i/riv/nazevZdroje	Journal of Natural Products
http://linked.open...in/vavai/riv/obor	GM
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	14 (xsd:int)
http://linked.open...vavai/riv/projekt	Anti-inflammatory activity of plant quinones Biomolecular centre
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	74
http://linked.open...iv/tvurceVysledku	Bartoš, M. Kokoška, L. Landa, Přemysl Marek, R. Chudík, S. Dall’Acqua, S. Hošek, J. Innocenti, G. Kartal, M. Kollár, P. Kutil, Zsófia Závalová, V. Šmejkal, K. Žemlička, M.
http://linked.open...ain/vavai/riv/wos	000289742300011
http://linked.open...n/vavai/riv/zamer	Mechanismy regulace růstu a vývoje rostlin na úrovni buněk, orgánů a celých organismů: fyziologické, genetické a molekulárně biologické základy Proteiny v metabolismu a při interakci organismů s prostředím
issn	0163-3864
number of pages	6 (xsd:int)
http://bibframe.org/vocab/doi	10.1021/np100638h

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