About: Pyrazolo[4,3-D]pyrimidines, processes for their preparation and methods for therapy

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The invention relates to new pyrazolo (4,3-d)pyrimidine derivatives and to their use in suitable utilities, especially diagnostic and therapeutic methods. It is an object of this invention to provide anticancer, anti-inflammatory, antiviral, antineurodegenerative, neurodepressive and immunosuppressive compounds having improved selectivity and efficiency index, i. E. that are less toxic yet more efficacious tha analogues known heretofore. It is an object of this invention to provide 3,5,7-trisubstituted pyrazolo(4,3-d)pyrimidines, which inhibit the cdks, cell proliferation, and/or induce apoptosis. A further object of the invention is to provide pharmaceutical composition, which comprises a 3,5,7-ftrisubstituted pyrazolo(4,3-d)pyrimidine and a pharmaceutically acceptable carrier. The invention relates to new pyrazolo (4,3-d)pyrimidine derivatives and to their use in suitable utilities, especially diagnostic and therapeutic methods. It is an object of this invention to provide anticancer, anti-inflammatory, antiviral, antineurodegenerative, neurodepressive and immunosuppressive compounds having improved selectivity and efficiency index, i. E. that are less toxic yet more efficacious tha analogues known heretofore. It is an object of this invention to provide 3,5,7-trisubstituted pyrazolo(4,3-d)pyrimidines, which inhibit the cdks, cell proliferation, and/or induce apoptosis. A further object of the invention is to provide pharmaceutical composition, which comprises a 3,5,7-ftrisubstituted pyrazolo(4,3-d)pyrimidine and a pharmaceutically acceptable carrier. (en)
Title	Pyrazolo[4,3-D]pyrimidines, processes for their preparation and methods for therapy Pyrazolo[4,3-D]pyrimidines, processes for their preparation and methods for therapy (en)
skos:prefLabel	Pyrazolo[4,3-D]pyrimidines, processes for their preparation and methods for therapy Pyrazolo[4,3-D]pyrimidines, processes for their preparation and methods for therapy (en)
skos:notation	RIV/61389030:_____/10:00352737!RIV11-GA0-61389030
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(GA301/08/1649), P(GA522/09/1576)
http://linked.open...cisloPatentuVzoru	EP1348707
http://linked.open...eleniPatentuVzoru	2010-08-25 (xsd:date)
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Havlíček, Libor Kryštof, Vladimír Strnad, Miroslav Lenobel, René Moravcová, Daniela
http://linked.open.../riv/druhVysledku	P - Patent
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav experimentální botaniky AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	283528
http://linked.open...ai/riv/idVysledku	RIV/61389030:_____/10:00352737
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Pyrazolo[4,3-D]pyrimidines; processes; preparation; methods; therapy (en)
http://linked.open.../riv/klicoveSlovo	methods therapy 3-D]pyrimidines preparation processes Pyrazolo[4
http://linked.open...ontrolniKodProRIV	[2F951CDB2F27]
http://linked.open.../licencniPoplatek	A - Poskytovatel licence na výsledek požaduje licenční poplatek
http://linked.open...ydaniPatentuVzoru	Mnichov
http://linked.open...atelePatentuVzoru	The European Patent Office (EPO) http://v3.espacenet.com/publicationDetails/originalDocument?FT=D&date=20100825&DB=EPODOC&locale=en_EP&CC=EP&NR=1348707B1&KC=B1
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Modulation of cell division of normal and cancer cells by cyclin-dependent kinase inhibitors Development of biospecific ligands for affinity chromatography of cytokinin related proteins.
http://linked.open...UplatneniVysledku	2010
http://linked.open...ydaniPatentuVzoru	DE - Spolková republika Německo
http://linked.open...iv/tvurceVysledku	Havlíček, Libor Kryštof, Vladimír Strnad, Miroslav Lenobel, René Moravcová, Daniela
http://linked.open...mniOchranaPatentu	A - EPO (Evropský patentový úřad)
http://linked.open...avai/riv/vlastnik	Ústav experimentální botaniky AV ČR, v. v. i., Univerzita Palackého v Olomouci
http://linked.open...itiJinymSubjektem	A - Nabytí licence je nutné vždy
http://linked.open...uzitiPatentuVzoru	B - Využívaný třetí stranou na základě licenční smlouvy
http://linked.open...stnikPatentuVzoru	Ústav experimentální botaniky AV ČR, v. v. i., Univerzita Palackého v Olomouci

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