About: Arabidopsis RAB geranylgeranyl transferase beta-subunit mutant is constitutively photomorphogenic, and has shoot growth and gravitropic defects

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About: Arabidopsis RAB geranylgeranyl transferase beta-subunit mutant is constitutively photomorphogenic, and has shoot growth and gravitropic defects Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	RAB GTPases are key regulators of intracellular vesicle transport. They are modified by geranylgeranylation catalyzed by the RAB geranylgeranyl transferase (RAB-GGT). Here, we show that RAB-GGT activity is significantly reduced in two homozygous mutants of the major Arabidopsis beta-subunit of RAB-GGT (AtRGTB1), resulting in unprenylated RAB GTPases accumulation in the cytoplasm. Both endocytosis and exocytosis are downregulated in rgtb1 homozygotes defective in shoot growth and morphogenesis. Root gravitropism is normal in rgtb1 roots, but is significantly compromised in shoots. Mutants are defective in etiolation and show constitutive photomorphogenic phenotypes that cannot be rescued by brassinosteroid treatment, similarly to the secretory det3 mutant. Transcriptomic analysis revealed an upregulation of specific RAB GTPases in etiolated wild-type plants. These data suggest that the downregulation of the secretory pathway is interpreted as a photomorphogenic signal in Arabidopsis. RAB GTPases are key regulators of intracellular vesicle transport. They are modified by geranylgeranylation catalyzed by the RAB geranylgeranyl transferase (RAB-GGT). Here, we show that RAB-GGT activity is significantly reduced in two homozygous mutants of the major Arabidopsis beta-subunit of RAB-GGT (AtRGTB1), resulting in unprenylated RAB GTPases accumulation in the cytoplasm. Both endocytosis and exocytosis are downregulated in rgtb1 homozygotes defective in shoot growth and morphogenesis. Root gravitropism is normal in rgtb1 roots, but is significantly compromised in shoots. Mutants are defective in etiolation and show constitutive photomorphogenic phenotypes that cannot be rescued by brassinosteroid treatment, similarly to the secretory det3 mutant. Transcriptomic analysis revealed an upregulation of specific RAB GTPases in etiolated wild-type plants. These data suggest that the downregulation of the secretory pathway is interpreted as a photomorphogenic signal in Arabidopsis. (en)
Title	Arabidopsis RAB geranylgeranyl transferase beta-subunit mutant is constitutively photomorphogenic, and has shoot growth and gravitropic defects Arabidopsis RAB geranylgeranyl transferase beta-subunit mutant is constitutively photomorphogenic, and has shoot growth and gravitropic defects (en)
skos:prefLabel	Arabidopsis RAB geranylgeranyl transferase beta-subunit mutant is constitutively photomorphogenic, and has shoot growth and gravitropic defects Arabidopsis RAB geranylgeranyl transferase beta-subunit mutant is constitutively photomorphogenic, and has shoot growth and gravitropic defects (en)
skos:notation	RIV/61389030:_____/10:00350388!RIV11-GA0-61389030
http://linked.open...avai/riv/aktivita	P V Z
http://linked.open...avai/riv/aktivity	P(GP204/06/P467), P(KJB600380802), P(LC06034), V, Z(AV0Z50380511), Z(MSM0021620858)
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Soukupová, Hana Synek, Lukáš Žárský, Viktor Hála, Michal
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav experimentální botaniky AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	247610
http://linked.open...ai/riv/idVysledku	RIV/61389030:_____/10:00350388
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	RAB GTPases; cell expansion; photomorphogenesis (en)
http://linked.open.../riv/klicoveSlovo	RAB GTPases photomorphogenesis cell expansion
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[C009D9C88522]
http://linked.open...i/riv/nazevZdroje	Plant Journal
http://linked.open...in/vavai/riv/obor	EA
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Transcriptome of the exo70A1 mutant and cellular roles of EXO70A1, a putative subunit of the exocyst complex, in Arabidopsis thaliana Regulation of morphogenesis of plant cells and organs Rab GTPases prenylation complex in Arabidopsis thaliana and its role in cell morphogenesis
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	62
http://linked.open...iv/tvurceVysledku	Hála, Michal Žárský, Viktor Soukupová, Hana Synek, Lukáš
http://linked.open...ain/vavai/riv/wos	000277609500007
http://linked.open...n/vavai/riv/zamer	Mechanismy regulace růstu a vývoje rostlin na úrovni buněk, orgánů a celých organismů: fyziologické, genetické a molekulárně biologické základy Signaling and cellular response mechanisms
issn	0960-7412
number of pages	13 (xsd:int)

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