About: Pyrazolo[4,3-D]pyrimidines, processes for their preparation and methods for therapy

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The invention relates to new trisubstituted pyrazolo[4,3-d]pyrimidine derivatives and to their use in suitable utilities, especially diagnostic and therapeutic methods.The compounds are anticancer, anti-inflammatory, antiviral, antineurodegenerative, neurodepressive and immunosuppressive, they have improved selectivity and efficiency index, i.e. that are less toxic yet more efficacious than analogues known.It is an object of this invention to provide 3-, 5-, 7-trisubstituted pyrazolo[4,3-d]pyrimidines, which inhibit the cdks, cell proliferation, and/or induce apoptosis. A further object of the invention is to provide a method for inhibiting cell proliferation and inflammatory diseases to a mammal in need of an effective amount.The solution of this object are 3-, 5-, 7-trisubstituted pyrazolo[4,3-d]pyrimidines of the formula I. The invention relates to new trisubstituted pyrazolo[4,3-d]pyrimidine derivatives and to their use in suitable utilities, especially diagnostic and therapeutic methods.The compounds are anticancer, anti-inflammatory, antiviral, antineurodegenerative, neurodepressive and immunosuppressive, they have improved selectivity and efficiency index, i.e. that are less toxic yet more efficacious than analogues known.It is an object of this invention to provide 3-, 5-, 7-trisubstituted pyrazolo[4,3-d]pyrimidines, which inhibit the cdks, cell proliferation, and/or induce apoptosis. A further object of the invention is to provide a method for inhibiting cell proliferation and inflammatory diseases to a mammal in need of an effective amount.The solution of this object are 3-, 5-, 7-trisubstituted pyrazolo[4,3-d]pyrimidines of the formula I. (en)
Title	Pyrazolo[4,3-D]pyrimidines, processes for their preparation and methods for therapy Pyrazolo[4,3-D]pyrimidines, processes for their preparation and methods for therapy (en)
skos:prefLabel	Pyrazolo[4,3-D]pyrimidines, processes for their preparation and methods for therapy Pyrazolo[4,3-D]pyrimidines, processes for their preparation and methods for therapy (en)
skos:notation	RIV/61389030:_____/10:00349834!RIV11-GA0-61389030
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(GA301/08/1649), P(GA522/09/1576)
http://linked.open...cisloPatentuVzoru	US7745450
http://linked.open...eleniPatentuVzoru	2010-06-29 (xsd:date)
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Havlíček, Libor Kryštof, Vladimír Strnad, Miroslav Lenobel, René Moravcová, Daniela
http://linked.open.../riv/druhVysledku	P - Patent
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav experimentální botaniky AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	283527
http://linked.open...ai/riv/idVysledku	RIV/61389030:_____/10:00349834
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	pyrazolo[4,3-d]pyrimidines; anticancer; anti-inflamatory (en)
http://linked.open.../riv/klicoveSlovo	anticancer anti-inflamatory 3-d]pyrimidines pyrazolo[4
http://linked.open...ontrolniKodProRIV	[C5C37016531C]
http://linked.open.../licencniPoplatek	A - Poskytovatel licence na výsledek požaduje licenční poplatek
http://linked.open...ydaniPatentuVzoru	USA
http://linked.open...atelePatentuVzoru	United States Patent and Trademark Office http://v3.espacenet.com/publicationDetails/originalDocument?CC=US&NR=7745450B2&KC=B2&FT=D&date=20100629&DB=EPODOC&locale=en_EP
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Modulation of cell division of normal and cancer cells by cyclin-dependent kinase inhibitors Development of biospecific ligands for affinity chromatography of cytokinin related proteins.
http://linked.open...UplatneniVysledku	2010
http://linked.open...ydaniPatentuVzoru	US - Spojené státy americké
http://linked.open...iv/tvurceVysledku	Havlíček, Libor Kryštof, Vladimír Strnad, Miroslav Lenobel, René Moravcová, Daniela
http://linked.open...mniOchranaPatentu	B - USTPO (Úřad pro patenty a ochranné známky USA)
http://linked.open...avai/riv/vlastnik	Ústav experimentální botaniky AV ČR, v. v. i., Univerzita Palackého v Olomouci
http://linked.open...itiJinymSubjektem	A - Nabytí licence je nutné vždy
http://linked.open...uzitiPatentuVzoru	B - Využívaný třetí stranou na základě licenční smlouvy
http://linked.open...stnikPatentuVzoru	Ústav experimentální botaniky AV ČR, v. v. i., Univerzita Palackého v Olomouci

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