About: Cytotoxic Activities of Several Geranyl-Substituted Flavanones

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Nine geranylated flavanones isolatér from the fruits of Paulownia tomentosa and two from the roots of Morus alba were examinated for cytotoxicity to selected human cancor cell lines and normal human fibroblasts. Cytotoxicity was determined in vitro using a calcein AM cytotoxicity assay. Cytotoxicity for the THP-1 monocytic leukemia cell line was tested using erythrosin B cell staining. The geranylated compounds tested were compared with the known simple flavanone standards taxifolin (1), naringenin (2), and hesperetin (3), and with the standard anticancer druha olomoucine II, diaziquone and oxaliplatin and antineoplastic compound camptothecin, and showed different levels of cytotoxicity. The effect of structural changes on cytotoxic aktivity, including geranyl substitution of the flavanone skeleton and the oxidation pattern of ring B of the flavanones, are discussed. Nine geranylated flavanones isolatér from the fruits of Paulownia tomentosa and two from the roots of Morus alba were examinated for cytotoxicity to selected human cancor cell lines and normal human fibroblasts. Cytotoxicity was determined in vitro using a calcein AM cytotoxicity assay. Cytotoxicity for the THP-1 monocytic leukemia cell line was tested using erythrosin B cell staining. The geranylated compounds tested were compared with the known simple flavanone standards taxifolin (1), naringenin (2), and hesperetin (3), and with the standard anticancer druha olomoucine II, diaziquone and oxaliplatin and antineoplastic compound camptothecin, and showed different levels of cytotoxicity. The effect of structural changes on cytotoxic aktivity, including geranyl substitution of the flavanone skeleton and the oxidation pattern of ring B of the flavanones, are discussed. (en)
Title	Cytotoxic Activities of Several Geranyl-Substituted Flavanones Cytotoxic Activities of Several Geranyl-Substituted Flavanones (en)
skos:prefLabel	Cytotoxic Activities of Several Geranyl-Substituted Flavanones Cytotoxic Activities of Several Geranyl-Substituted Flavanones (en)
skos:notation	RIV/61389030:_____/10:00349184!RIV11-GA0-61389030
http://linked.open...avai/riv/aktivita	P S V Z
http://linked.open...avai/riv/aktivity	P(GA301/08/1649), P(GD522/08/H003), P(LC06030), S, V, Z(AV0Z50380511), Z(MSM0021622413), Z(MSM6198959216)
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Doležal, Karel Svačinová, Jana
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav experimentální botaniky AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	252658
http://linked.open...ai/riv/idVysledku	RIV/61389030:_____/10:00349184
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	flavanones; geranyl; cytotoxicity (en)
http://linked.open.../riv/klicoveSlovo	cytotoxicity geranyl flavanones
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[8F609EBFD380]
http://linked.open...i/riv/nazevZdroje	Journal of Natural Products
http://linked.open...in/vavai/riv/obor	BO
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	15 (xsd:int)
http://linked.open...vavai/riv/projekt	Biomolecular centre Integration of doctoral studies in biochemistry, plant physiology and biophysics Modulation of cell division of normal and cancer cells by cyclin-dependent kinase inhibitors
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	73
http://linked.open...iv/tvurceVysledku	Doležal, Karel Urbanová, M. Marek, R. Chudík, S. Dall’Acqua, S. Innocenti, G. Kartal, M. Kollár, P. Závalová, V. Šmejkal, K. Svačinová, Jana Csöllei, M. Julínek, O. Schneiderová, K. Šlapetová, T.
http://linked.open...ain/vavai/riv/wos	000276950000011
http://linked.open...n/vavai/riv/zamer	Mechanismy regulace růstu a vývoje rostlin na úrovni buněk, orgánů a celých organismů: fyziologické, genetické a molekulárně biologické základy Proteiny v metabolismu a při interakci organismů s prostředím Modulation of signalling and regulatory pathways in normal and cancer cells
issn	0163-3864
number of pages	5 (xsd:int)

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