| Attributes | Values |
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| rdf:type
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| Description
| - Jaderné receptory PPAR jsou transkripční faktory aktivované specifickými ligandy. Tyto re-ceptory mají důležitou úlohu v průběhu karcinogeneze, zánětů, aterosklerózy, metabolismu lipidů a diabetu. Aktivace PPAR může potlačovat růst a diferenciaci lidských nádorových buněk. Přesný mechanismus jejich působení není dosud znám. Cílem této práce bylo určit vliv syntetických ligandů PPAR? a PPAR? na životaschopnost, proliferaci, diferenciaci, apoptózu a expresy vybraných proteinů řídících buněčný cyklus u buněk nádorů mozku. (cs)
- The nuclear receptors PPARs (peroxisome proliferator-activated receptors) are transcription factors activated by specific ligands. PPARs play an important role in carcinogenesis, in-flammation, atherosclerosis, lipid metabolism and diabetes. There is evidence that activation of PPARs by specific ligands is able to suppress the growth of different types of human can-cer by mechanisms including the growth arrest, apoptosis and induction of differentiation, although the detailed signalling pathways have not been completely elucidated to date. The aim of our study was to determine whether synthetic ligands of PPAR alpha and PPAR gam-ma could affect the viability, proliferation, differentiation, apoptosis and expression of some cell cycle related proteins in glial tumor cell lines.
- The nuclear receptors PPARs (peroxisome proliferator-activated receptors) are transcription factors activated by specific ligands. PPARs play an important role in carcinogenesis, in-flammation, atherosclerosis, lipid metabolism and diabetes. There is evidence that activation of PPARs by specific ligands is able to suppress the growth of different types of human can-cer by mechanisms including the growth arrest, apoptosis and induction of differentiation, although the detailed signalling pathways have not been completely elucidated to date. The aim of our study was to determine whether synthetic ligands of PPAR alpha and PPAR gam-ma could affect the viability, proliferation, differentiation, apoptosis and expression of some cell cycle related proteins in glial tumor cell lines. (en)
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| Title
| - Peroxisome proliferator-activated receptors (PPAR) agonists affect cell viability, apoptosis and expression of cell cycle related proteins in cell lines of glial brain tumors
- Ligandy receptorů aktivovaného proliferátoru peroxisomů (PPAR) ovlivňují životaschopnost, apoptózu a expresi proteinů řídících buněčný cyklus u buněk nádorů mozku (cs)
- Peroxisome proliferator-activated receptors (PPAR) agonists affect cell viability, apoptosis and expression of cell cycle related proteins in cell lines of glial brain tumors (en)
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| skos:prefLabel
| - Peroxisome proliferator-activated receptors (PPAR) agonists affect cell viability, apoptosis and expression of cell cycle related proteins in cell lines of glial brain tumors
- Ligandy receptorů aktivovaného proliferátoru peroxisomů (PPAR) ovlivňují životaschopnost, apoptózu a expresi proteinů řídících buněčný cyklus u buněk nádorů mozku (cs)
- Peroxisome proliferator-activated receptors (PPAR) agonists affect cell viability, apoptosis and expression of cell cycle related proteins in cell lines of glial brain tumors (en)
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| skos:notation
| - RIV/61389030:_____/05:00028178!RIV06-AV0-61389030
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| http://linked.open.../vavai/riv/strany
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
| - P(NC6726), Z(AV0Z50380511), Z(MSM6198959216)
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/61389030:_____/05:00028178
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - PPAR; glioplasma; cell cycle (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...vavai/riv/projekt
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| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Bartoš, Jan
- Doležel, Jaroslav
- Ehrmann, J.
- Kolář, Z.
- Malíková, J.
- Straková, N.
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| http://linked.open...n/vavai/riv/zamer
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| issn
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| number of pages
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