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| Description
| - Rad17 is involved in DNA checkpoint control in yeast and human cells. A homologue of this gene as well as other genes of the pathway (the 9-1-1 complex) are present in Arabidopsis and share conserved sequence domains with their yeast and human counterparts. DNA-damaging agents induce AtRAD17 transcriptionally. AtRAD17 mutants show increased sensitivity to the DNA-damaging chemicals bleomycin and mitomycin C (MMC), which can be reversed by complementation, suggesting that the loss of function of Rad17 disturbs DNA repair in plant cells. Our results are further confirmed by the phenotype of a mutant of the 9-1-1 complex (Rad9), which is also sensitive to the same chemicals. AtRAD9 and AtRAD17 seem to be epistatic as the double mutant is not more sensitive to the chemicals than the single mutants. The mutants show a delay in the general repair of double-strand breaks (DSBs). However, frequencies of intrachromosomal homologous recombination (HR) are enhanced. Nevertheless, the mutants a...
- Rad17 is involved in DNA checkpoint control in yeast and human cells. A homologue of this gene as well as other genes of the pathway (the 9-1-1 complex) are present in Arabidopsis and share conserved sequence domains with their yeast and human counterparts. DNA-damaging agents induce AtRAD17 transcriptionally. AtRAD17 mutants show increased sensitivity to the DNA-damaging chemicals bleomycin and mitomycin C (MMC), which can be reversed by complementation, suggesting that the loss of function of Rad17 disturbs DNA repair in plant cells. Our results are further confirmed by the phenotype of a mutant of the 9-1-1 complex (Rad9), which is also sensitive to the same chemicals. AtRAD9 and AtRAD17 seem to be epistatic as the double mutant is not more sensitive to the chemicals than the single mutants. The mutants show a delay in the general repair of double-strand breaks (DSBs). However, frequencies of intrachromosomal homologous recombination (HR) are enhanced. Nevertheless, the mutants a... (en)
- Rad17 vystupuje v kvasinkách a lidských buňkách jako kontrolní gen DNA. Jeho homolog stejně jako homology dalších genů této dráhy (9_1_1 komplex) se vyskytuje u huseníčku a sdílí s nimi konzervované sekvence a domény. Látky poškozující DNA indukují transkripčně AtRAD17. Mutanty pak vykazují zvýšenou citlivost k látkám jako bleomycin nebo mitomycin C (MMC). Mutovaný fenotyp je kompenzován komplementací, což naznačuje, že ztráta funkce Rad17 narušuje reparaci DNA v rostlinných buňkách. Naše výsledky potvrzuje také fenotyp mutanta komplexu 9-1-1 (Rad9), který je citlivý ke stejným chemikáliím. Ukazuje se, že AtRAD9 a AtRAD17 jsou epistatické, protože dvojitý mutant není citlivější než samostatné. Mutanty vykazují prodlevu obecné reparace dvojvláknových zlomů (DSB) DNA. Frekvence intrachromozomálních homologiích rekombinací (HR) je však zvýšena. Nicméně mutanty jsou proficientní pro další indukci HR genotoxickým stresem. Naše výsledky naznačují, že mutovaná dráha Rad17 je spojena s celk... (cs)
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| Title
| - The Rad17 homologue of Arabidopsis is involved in the regulation of DNA damage repair and homologous recombination
- Homolog huseníčku Rad17 se zúčastňuje regulace reparace poškození DNA a homologní rekombinace (cs)
- The Rad17 homologue of Arabidopsis is involved in the regulation of DNA damage repair and homologous recombination (en)
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| skos:prefLabel
| - The Rad17 homologue of Arabidopsis is involved in the regulation of DNA damage repair and homologous recombination
- Homolog huseníčku Rad17 se zúčastňuje regulace reparace poškození DNA a homologní rekombinace (cs)
- The Rad17 homologue of Arabidopsis is involved in the regulation of DNA damage repair and homologous recombination (en)
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| skos:notation
| - RIV/61389030:_____/04:00109147!RIV/2005/AV0/A56005/N
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| http://linked.open.../vavai/riv/strany
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
| - P(GA521/01/1418), P(ME 534), P(ME 535), Z(AV0Z5038910)
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/61389030:_____/04:00109147
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - Arabidopsis; RAD17; RAD9 (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
| - GB - Spojené království Velké Británie a Severního Irska
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...vavai/riv/projekt
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| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Angelis, Karel
- Hartung, F.
- Chen, I. P.
- Heitzeberg, F.
- Orel, N.
- Puchta, H.
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| http://linked.open...n/vavai/riv/zamer
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| issn
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| number of pages
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