About: 2,6,8,9-Tetrasubstituted Purines as New CDK1 Inhibitors.

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About: 2,6,8,9-Tetrasubstituted Purines as New CDK1 Inhibitors. Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Purine inhibitors of cyclin-dependent kinases attract attention as potential anticancer drugs because their first representative roscovitine recently entered clinical trials. Although well described in terms of structure-activity relationships, we still present here a novel modification of the purine scaffold influencing their inhibitory properties. The introduced C-8 substituents, however, lowered the CDK inhibitory activity of roscovitine, whereas the antiproliferative potential of several derivatives remained high. Purine inhibitors of cyclin-dependent kinases attract attention as potential anticancer drugs because their first representative roscovitine recently entered clinical trials. Although well described in terms of structure-activity relationships, we still present here a novel modification of the purine scaffold influencing their inhibitory properties. The introduced C-8 substituents, however, lowered the CDK inhibitory activity of roscovitine, whereas the antiproliferative potential of several derivatives remained high. (en)
Title	2,6,8,9-Tetrasubstituted Purines as New CDK1 Inhibitors. 2,6,8,9-Tetrasubstituted Purines as New CDK1 Inhibitors. (en)
skos:prefLabel	2,6,8,9-Tetrasubstituted Purines as New CDK1 Inhibitors. 2,6,8,9-Tetrasubstituted Purines as New CDK1 Inhibitors. (en)
skos:notation	RIV/61389030:_____/03:56033101!RIV/2004/GA0/A56004/N
http://linked.open.../vavai/riv/strany	2993ů2996
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA301/02/0475), P(KJB6137301), Z(AV0Z5020903), Z(AV0Z5038910), Z(MSM 153100007)
http://linked.open...iv/cisloPeriodika	18
http://linked.open...vai/riv/dodaniDat	2004
http://linked.open...aciTvurceVysledku	Moravec, Jiří Havlíček, Libor Kryštof, Vladimír Hanuš, Jan Strnad, Miroslav Lenobel, René Moravcová, Daniela
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav experimentální botaniky AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	636799
http://linked.open...ai/riv/idVysledku	RIV/61389030:_____/03:56033101
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Purine inhibitors; cyclin-dependent kinases; roscovitine (en)
http://linked.open.../riv/klicoveSlovo	roscovitine Purine inhibitors cyclin-dependent kinases
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[C7817E8D3077]
http://linked.open...i/riv/nazevZdroje	Bioorganic and Medicinal Chemistry Letters
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	7 (xsd:int)
http://linked.open...cetTvurcuVysledku	10 (xsd:int)
http://linked.open...ocetUcastnikuAkce	0 (xsd:int)
http://linked.open...nichUcastnikuAkce	0 (xsd:int)
http://linked.open...vavai/riv/projekt	Purine inhibitors of cyclin-dependent kinases as anticancer and antimitotic compounds 8-Substituted Analogues of Cytokinins - Utilization of their Potential New Quality in Plant Research
http://linked.open...UplatneniVysledku	2003
http://linked.open...v/svazekPeriodika	13
http://linked.open...iv/tvurceVysledku	Havlíček, Libor Hanuš, Jan Kuzma, Marek Kryštof, Vladimír Moravec, Jiří Strnad, Miroslav Lenobel, René Otyepka, M. Moravcová, Daniela Fuksová, K.
http://linked.open...n/vavai/riv/zamer	Výzkum buněčné a molekulární biologie, genetiky, fyziologie a ekologie mikroorganizmů, mikrobní biotechnologie; studium imunitních procesů Physiological and genetical bases of plant development, cell cycle, morphogenesis, stress reactions and biotechnologies. Genome organisation and function http://linked.opendata.cz/resource/domain/vavai/zamer/MSM%20153100007
issn	0960-894X
number of pages	4 (xsd:int)

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