About: Antiapoptotic activity of synthetic and natural peptides.

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About: Antiapoptotic activity of synthetic and natural peptides. Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Our previous studies have shown that peptide mixtures separated from protein digests, as well as individual synthetic peptides are capable of significantly delaying the onset of apoptosis that occurs spontaneously at the decline phase of cell cultures (Franek et al., Biotechnol. Prog.18:155 (2002), Biotechnol. Prog.19:169 (2003)). The characteristic feature of the action of small peptides (two to six amino acid residues) on hybridoma, cultures was the millimolar concentration range needed to achieve significanFchanges of culture parameters. The observed favourable effects of peptides could not be explained by improvement of cell nutrition, because mixtures of free amino acids, constituting the peptides, did not exert comparable effects. The variety of peptides tested for their anti-apoptotic activity in mouse hybridoma cultures was now extended to peptides containing non-coded amino acids and D-amino acids. The apoptotic index Al (i.e. apoptotic cells / total cells) in control cultures at day 6 was (4 Our previous studies have shown that peptide mixtures separated from protein digests, as well as individual synthetic peptides are capable of significantly delaying the onset of apoptosis that occurs spontaneously at the decline phase of cell cultures (Franek et al., Biotechnol. Prog.18:155 (2002), Biotechnol. Prog.19:169 (2003)). The characteristic feature of the action of small peptides (two to six amino acid residues) on hybridoma, cultures was the millimolar concentration range needed to achieve significanFchanges of culture parameters. The observed favourable effects of peptides could not be explained by improvement of cell nutrition, because mixtures of free amino acids, constituting the peptides, did not exert comparable effects. The variety of peptides tested for their anti-apoptotic activity in mouse hybridoma cultures was now extended to peptides containing non-coded amino acids and D-amino acids. The apoptotic index Al (i.e. apoptotic cells / total cells) in control cultures at day 6 was (4 (en)
Title	Antiapoptotic activity of synthetic and natural peptides. Antiapoptotic activity of synthetic and natural peptides. (en)
skos:prefLabel	Antiapoptotic activity of synthetic and natural peptides. Antiapoptotic activity of synthetic and natural peptides. (en)
skos:notation	RIV/61389030:_____/03:56033067!RIV/2004/GA0/A56004/N
http://linked.open.../vavai/riv/strany	33
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA203/01/0083), Z(AV0Z5038910)
http://linked.open...vai/riv/dodaniDat	2004
http://linked.open...aciTvurceVysledku	Franěk, František
http://linked.open.../riv/druhVysledku	D - Článek ve sborníku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav experimentální botaniky AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	598561
http://linked.open...ai/riv/idVysledku	RIV/61389030:_____/03:56033067
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Apoptosis; hybridoma; size-exclusion chromatography (en)
http://linked.open.../riv/klicoveSlovo	Apoptosis size-exclusion chromatography hybridoma
http://linked.open...ontrolniKodProRIV	[5D47C7418226]
http://linked.open...v/mistoKonaniAkce	Ghent [BE]
http://linked.open...i/riv/mistoVydani	N/A
http://linked.open...i/riv/nazevZdroje	11th Euroconference on Apoptosis 'Cell death under the three towers'.
http://linked.open...in/vavai/riv/obor	CE
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	1 (xsd:int)
http://linked.open...ocetUcastnikuAkce	0 (xsd:int)
http://linked.open...nichUcastnikuAkce	0 (xsd:int)
http://linked.open...vavai/riv/projekt	Structure activity relationship of brassinollide-type plant growth regulators
http://linked.open...UplatneniVysledku	2003
http://linked.open...iv/tvurceVysledku	Franěk, František
http://linked.open...vavai/riv/typAkce	WRD - Světová
http://linked.open.../riv/zahajeniAkce	2003-10-25 (xsd:date)
http://linked.open...n/vavai/riv/zamer	Physiological and genetical bases of plant development, cell cycle, morphogenesis, stress reactions and biotechnologies. Genome organisation and function
number of pages	1 (xsd:int)
http://purl.org/ne...btex#hasPublisher	European Cell Death Organisation

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