About: Colloidally stable surface-modified iron oxide nanoparticles: preparation, characterization and anti-tumor activity

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Colloidally stable surface-modified iron oxide nanoparticles: preparation, characterization and anti-tumor activity Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Maghemite (γ-Fe2O3) nanoparticles were obtained by co-precipitation of Fe(II) and Fe(III) chlorides and subsequent oxidation with sodium hypochlorite and coated with poly(N,N-dimethylacrylamide-co-acrylic acid) [P(DMAAm-AA)]. They were characterized by a range of methods including transmission electron microscopy (TEM), elemental analysis, dynamic light scattering (DLS) and zeta potential measurements. The effect of superparamagnetic P(DMAAm-AA)-γ-Fe2O3 nanoparticles on oxidation of blood lipids, glutathione and proteins in blood serum was detected using 2-thiobarbituric acid and the ThioGlo fluorophore. Finally, mice received magnetic nanoparticles administered per os and the antitumor activity of the particles was tested on Lewis lung carcinoma (LLC) in male mice line С57ВL/6 as an experimental in vivo metastatic tumor model; the tumor size was measured and the number of metastases in lungs was determined. Surface-modified γ-Fe2O3 nanoparticles showed higher antitumor and antimetastatic activities than commercial CuFe2O4 particles and the conventional antitumor agent cisplatin. Maghemite (γ-Fe2O3) nanoparticles were obtained by co-precipitation of Fe(II) and Fe(III) chlorides and subsequent oxidation with sodium hypochlorite and coated with poly(N,N-dimethylacrylamide-co-acrylic acid) [P(DMAAm-AA)]. They were characterized by a range of methods including transmission electron microscopy (TEM), elemental analysis, dynamic light scattering (DLS) and zeta potential measurements. The effect of superparamagnetic P(DMAAm-AA)-γ-Fe2O3 nanoparticles on oxidation of blood lipids, glutathione and proteins in blood serum was detected using 2-thiobarbituric acid and the ThioGlo fluorophore. Finally, mice received magnetic nanoparticles administered per os and the antitumor activity of the particles was tested on Lewis lung carcinoma (LLC) in male mice line С57ВL/6 as an experimental in vivo metastatic tumor model; the tumor size was measured and the number of metastases in lungs was determined. Surface-modified γ-Fe2O3 nanoparticles showed higher antitumor and antimetastatic activities than commercial CuFe2O4 particles and the conventional antitumor agent cisplatin. (en)
Title	Colloidally stable surface-modified iron oxide nanoparticles: preparation, characterization and anti-tumor activity Colloidally stable surface-modified iron oxide nanoparticles: preparation, characterization and anti-tumor activity (en)
skos:prefLabel	Colloidally stable surface-modified iron oxide nanoparticles: preparation, characterization and anti-tumor activity Colloidally stable surface-modified iron oxide nanoparticles: preparation, characterization and anti-tumor activity (en)
skos:notation	RIV/61389013:_____/15:00442140!RIV15-AV0-61389013
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(7E12054), P(ED1.1.00/02.0109), P(LH14318)
http://linked.open...iv/cisloPeriodika	15 April
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Horák, Daniel Macková, Hana
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav makromolekulární chemie AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	70
http://linked.open...ai/riv/idVysledku	RIV/61389013:_____/15:00442140
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	iron oxide nanoparticle; poly(N,N-dimethylacrylamide-co-acrylic acid); protein oxidation (en)
http://linked.open.../riv/klicoveSlovo	N-dimethylacrylamide-co-acrylic acid) iron oxide nanoparticle protein oxidation poly(N
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[266EAE123F9C]
http://linked.open...i/riv/nazevZdroje	Journal of Magnetism and Magnetic Materials
http://linked.open...in/vavai/riv/obor	CD
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...vavai/riv/projekt	Biotechnology and Biomedicine Centre of the Academy of Sciences and Charles University Synthesis of polymer-coated magnetic nanoparticles for biomedicine Tools for minimally invasive diagnostics
http://linked.open...UplatneniVysledku	2015
http://linked.open...v/svazekPeriodika	380
http://linked.open...iv/tvurceVysledku	Horák, Daniel Macková, Hana Andriyaka, V. I. Chekhun, V. F. Chernishov, V. I. Donchenko, G. V. Kuzmenko, O. I. Palyvoda, O. M. Todor, I. N.
http://linked.open...ain/vavai/riv/wos	000349360800021
issn	0304-8853
number of pages	7 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.jmmm.2014.09.037

Faceted Search & Find service v1.16.118 as of Jun 21 2024

Alternative Linked Data Documents: ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 58 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software