About: Thermoresponsive polymer system based on poly(N-vinylcaprolactam) intended for local radiotherapy applications

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Brachytherapy represents effective local therapy of unresectable solid tumors with very few side effects. Radiolabeled thermoresponsive polymers offer almost noninvasive approach to brachytherapy applications. A radioiodinated, water-soluble, thermosensitive poly(N-vinylcaprolactam) (PVCL) polymer was prepared using two approaches. The direct copolymerization with N-methacryloyl-l-tyrosinamide, as well as end-capping of carboxy-terminated PVCL homopolymer with tyramine, were used. In both cases the product was successfully radiolabeled with 125I. The obtained polymers demonstrate cloud-point temperature (TC) values in the range of 33–35 °C in all the studied solvent systems (water, PBS (pH 7.4) and physiological saline solution). Above the cloud point temperature, the molecularly dissolved polymer is macroprecipitated from the solution. The TC values close to the human body temperature of this biocompatible poly(N-vinylcaprolactam) polymer makes it a promising material intended for local therapy of solid tumors. Brachytherapy represents effective local therapy of unresectable solid tumors with very few side effects. Radiolabeled thermoresponsive polymers offer almost noninvasive approach to brachytherapy applications. A radioiodinated, water-soluble, thermosensitive poly(N-vinylcaprolactam) (PVCL) polymer was prepared using two approaches. The direct copolymerization with N-methacryloyl-l-tyrosinamide, as well as end-capping of carboxy-terminated PVCL homopolymer with tyramine, were used. In both cases the product was successfully radiolabeled with 125I. The obtained polymers demonstrate cloud-point temperature (TC) values in the range of 33–35 °C in all the studied solvent systems (water, PBS (pH 7.4) and physiological saline solution). Above the cloud point temperature, the molecularly dissolved polymer is macroprecipitated from the solution. The TC values close to the human body temperature of this biocompatible poly(N-vinylcaprolactam) polymer makes it a promising material intended for local therapy of solid tumors. (en)
Title	Thermoresponsive polymer system based on poly(N-vinylcaprolactam) intended for local radiotherapy applications Thermoresponsive polymer system based on poly(N-vinylcaprolactam) intended for local radiotherapy applications (en)
skos:prefLabel	Thermoresponsive polymer system based on poly(N-vinylcaprolactam) intended for local radiotherapy applications Thermoresponsive polymer system based on poly(N-vinylcaprolactam) intended for local radiotherapy applications (en)
skos:notation	RIV/61389013:_____/15:00439963!RIV15-MPO-61389013
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(FR-TI4/625), P(LH14079)
http://linked.open...iv/cisloPeriodika	April
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Štěpánek, Petr Černoch, Peter Hrubý, Martin Kučka, Jan Bakaeva, Zulfiya Petrova, Svetlana
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav makromolekulární chemie AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	465
http://linked.open...ai/riv/idVysledku	RIV/61389013:_____/15:00439963
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	poly(N-vinylcaprolactam); tumor; brachytherapy (en)
http://linked.open.../riv/klicoveSlovo	tumor poly(N-vinylcaprolactam) brachytherapy
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[81F16D1C52DB]
http://linked.open...i/riv/nazevZdroje	Applied Radiation and Isotopes
http://linked.open...in/vavai/riv/obor	CD
http://linked.open...ichTvurcuVysledku	6 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	New derivatives of 5-azacytosine nucleosides like demethylating therapeutics: identification of clinical candidates and efficiency biomarkers. Thermoresponsive polymer catalytic depots: in situ shaped reactors intended for biomedical purposes
http://linked.open...UplatneniVysledku	2015
http://linked.open...v/svazekPeriodika	98
http://linked.open...iv/tvurceVysledku	Hrubý, Martin Černoch, Peter Štěpánek, Petr Kučka, Jan Černochová, Zulfiya Petrova, Svetlana
issn	0969-8043
number of pages	6 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.apradiso.2015.01.005

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