About: Exploiting end group functionalization for the design of antifouling bioactive brushes

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About: Exploiting end group functionalization for the design of antifouling bioactive brushes Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Biologically active surfaces are essential in many applications in the fields of biosensing, bioimplants, and tissue engineering. However, the introduction of bioactive motifs without impairment of their ability to resist non-specific interactions with biological media remains a challenge. Herein, we present a straightforward, facile strategy for the creation of bioactive surfaces based on the end-group biofunctionalization of state-of-the-art polymer brushes via an ultra-fast Diels–Alder “click reaction. Surface-initiated atom transfer radical polymerization is employed to grow antifouling polymers preserving the end groups. These groups are then further converted to a reactive cyclopentadienyl moiety and exploited for the immobilization of biomolecules on the topmost layer of the brush. The minimal chemical modification of the antifouling polymer brush accounts for the full preservation of the fouling resistance of the surface even after biofunctionalization, which is critical for the aforementioned applications. Biologically active surfaces are essential in many applications in the fields of biosensing, bioimplants, and tissue engineering. However, the introduction of bioactive motifs without impairment of their ability to resist non-specific interactions with biological media remains a challenge. Herein, we present a straightforward, facile strategy for the creation of bioactive surfaces based on the end-group biofunctionalization of state-of-the-art polymer brushes via an ultra-fast Diels–Alder “click reaction. Surface-initiated atom transfer radical polymerization is employed to grow antifouling polymers preserving the end groups. These groups are then further converted to a reactive cyclopentadienyl moiety and exploited for the immobilization of biomolecules on the topmost layer of the brush. The minimal chemical modification of the antifouling polymer brush accounts for the full preservation of the fouling resistance of the surface even after biofunctionalization, which is critical for the aforementioned applications. (en)
Title	Exploiting end group functionalization for the design of antifouling bioactive brushes Exploiting end group functionalization for the design of antifouling bioactive brushes (en)
skos:prefLabel	Exploiting end group functionalization for the design of antifouling bioactive brushes Exploiting end group functionalization for the design of antifouling bioactive brushes (en)
skos:notation	RIV/61389013:_____/14:00428662!RIV15-GA0-61389013
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(ED1.1.00/02.0109), P(GAP108/11/1857), P(GAP205/12/1702)
http://linked.open...iv/cisloPeriodika	13
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Brynda, Eduard Pop-Georgievski, Ognen Rodriguez-Emmenegger, Cesar de los Santos Pereira, Andres Kuzmyn, Andrii
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav makromolekulární chemie AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	16082
http://linked.open...ai/riv/idVysledku	RIV/61389013:_____/14:00428662
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	click chemistry; end-group functionalization; non-fouling (en)
http://linked.open.../riv/klicoveSlovo	non-fouling click chemistry end-group functionalization
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[62A9EE1B0236]
http://linked.open...i/riv/nazevZdroje	Polymer Chemistry
http://linked.open...in/vavai/riv/obor	CD
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	Biotechnology and Biomedicine Centre of the Academy of Sciences and Charles University Polymer biomaterials for vascular tissue engineering Interaction of complex biological fluids with synthetic surfaces resistant to protein adsorption
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	5
http://linked.open...iv/tvurceVysledku	Brynda, Eduard Pop-Georgievski, Ognen Rodriguez-Emmenegger, Cesar de los Santos Pereira, Andres Bruns, M. Kuzmyn, Andrii
http://linked.open...ain/vavai/riv/wos	000337097500023
issn	1759-9954
number of pages	8 (xsd:int)
http://bibframe.org/vocab/doi	10.1039/C4PY00281D

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