About: Colloidal polyaniline dispersions: Antibacterial activity, cytotoxicity and neutrophil oxidative burst

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Polyaniline colloids rank among promising application forms of this conducting polymer. Cytotoxicity, antibacterial activity, and neutrophil oxidative burst tests were performed on cells treated with colloidal polyaniline dispersions. The antibacterial effect of colloidal polyaniline against gram-positive and gram-negative bacteria was most pronounced for Bacillus cereus and Escherichia coil, with a minimum inhibitory concentration of 3500 mu g mL(-1). The data recorded on human keratinocyte (HaCaT) and a mouse embryonic fibroblast (NIH/3T3) cell lines using an MIT assay and flow cytometry indicated a concentration-dependent cytotoxicity of colloid, with the absence of cytotoxic effect at around 150 mu g mL(-1). The neutrophil oxidative burst test then showed that colloidal polyaniline, in concentrations <150 mu g mL(-1), was not able to stimulate the production of reactive oxygen species in neutrophils and whole human blood. However, it worked efficiently as a scavenger of those already formed. (C) 2014 Elsevier B.V. All rights reserved. Polyaniline colloids rank among promising application forms of this conducting polymer. Cytotoxicity, antibacterial activity, and neutrophil oxidative burst tests were performed on cells treated with colloidal polyaniline dispersions. The antibacterial effect of colloidal polyaniline against gram-positive and gram-negative bacteria was most pronounced for Bacillus cereus and Escherichia coil, with a minimum inhibitory concentration of 3500 mu g mL(-1). The data recorded on human keratinocyte (HaCaT) and a mouse embryonic fibroblast (NIH/3T3) cell lines using an MIT assay and flow cytometry indicated a concentration-dependent cytotoxicity of colloid, with the absence of cytotoxic effect at around 150 mu g mL(-1). The neutrophil oxidative burst test then showed that colloidal polyaniline, in concentrations <150 mu g mL(-1), was not able to stimulate the production of reactive oxygen species in neutrophils and whole human blood. However, it worked efficiently as a scavenger of those already formed. (C) 2014 Elsevier B.V. All rights reserved. (en)
Title	Colloidal polyaniline dispersions: Antibacterial activity, cytotoxicity and neutrophil oxidative burst Colloidal polyaniline dispersions: Antibacterial activity, cytotoxicity and neutrophil oxidative burst (en)
skos:prefLabel	Colloidal polyaniline dispersions: Antibacterial activity, cytotoxicity and neutrophil oxidative burst Colloidal polyaniline dispersions: Antibacterial activity, cytotoxicity and neutrophil oxidative burst (en)
skos:notation	RIV/61389013:_____/14:00428657!RIV15-GA0-61389013
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(EE2.3.30.0030), P(GA13-08944S)
http://linked.open...iv/cisloPeriodika	APR 2014
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Stejskal, Jaroslav
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav makromolekulární chemie AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	7746
http://linked.open...ai/riv/idVysledku	RIV/61389013:_____/14:00428657
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Cytotoxicity; Apoptosis; Necrosis (en)
http://linked.open.../riv/klicoveSlovo	Necrosis Apoptosis Cytotoxicity
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[0ABA1F021967]
http://linked.open...i/riv/nazevZdroje	Colloids and Surfaces B-Biointerfaces
http://linked.open...in/vavai/riv/obor	CD
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...vavai/riv/projekt	Interactions of Conducting Polymers with Cells. Development of human resources in the field of cell biology
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	116
http://linked.open...iv/tvurceVysledku	Kašpárková, V. Stejskal, Jaroslav Sáha, P. Lehocký, M. Perečko, Tomáš Humpolíček, P. Hauerlandova, I. Kuceková, Z.
http://linked.open...ain/vavai/riv/wos	000335706100054
issn	0927-7765
number of pages	7 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.colsurfb.2014.01.027

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