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  • Oncolytic viruses are among the most powerful and selective cancer therapeutics under development and are showing robust activity in clinical trials, particularly when administered directly into tumor nodules. However, their intravenous administration to treat metastatic disease has been stymied by unfavorable pharmacokinetics and inefficient accumulation in and penetration through tumors. Combining drug stealthing and ultrasound-induced cavitation may ultimately enhance the efficacy of a range of powerful therapeutics, thereby improving the treatment of metastatic cancer.
  • Oncolytic viruses are among the most powerful and selective cancer therapeutics under development and are showing robust activity in clinical trials, particularly when administered directly into tumor nodules. However, their intravenous administration to treat metastatic disease has been stymied by unfavorable pharmacokinetics and inefficient accumulation in and penetration through tumors. Combining drug stealthing and ultrasound-induced cavitation may ultimately enhance the efficacy of a range of powerful therapeutics, thereby improving the treatment of metastatic cancer. (en)
Title
  • Enhanced tumor uptake and penetration of virotherapy using polymer stealthing and focused ultrasound
  • Enhanced tumor uptake and penetration of virotherapy using polymer stealthing and focused ultrasound (en)
skos:prefLabel
  • Enhanced tumor uptake and penetration of virotherapy using polymer stealthing and focused ultrasound
  • Enhanced tumor uptake and penetration of virotherapy using polymer stealthing and focused ultrasound (en)
skos:notation
  • RIV/61389013:_____/13:00399052!RIV14-AV0-61389013
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • I
http://linked.open...iv/cisloPeriodika
  • 22
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  • 72937
http://linked.open...ai/riv/idVysledku
  • RIV/61389013:_____/13:00399052
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  • cancer; intravenous; adenovirus (en)
http://linked.open.../riv/klicoveSlovo
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  • US - Spojené státy americké
http://linked.open...ontrolniKodProRIV
  • [28CE283E0FB1]
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  • JNCI-Journal of the National Cancer Institute
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  • 105
http://linked.open...iv/tvurceVysledku
  • Ulbrich, Karel
  • Seymour, L. W.
  • Šubr, Vladimír
  • Choi, J.
  • Kostka, Libor
  • Carlisle, R.
  • Bazan-Peregrino, M.
  • Coussios, C. C.
  • Laga, R.
http://linked.open...ain/vavai/riv/wos
  • 000327539000007
issn
  • 0027-8874
number of pages
http://bibframe.org/vocab/doi
  • 10.1093/jnci/djt305
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