About: Hydrolytically degradable polymer micelles for drug delivery: a SAXS/SANS kinetic study

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	We report kinetic studies of therapeutically highly potent polymerdrug conjugates consisting of amphiphilic N-(2-hydroxypropyl) methacrylamide (HPMA)-based copolymers bearing the anticancer drug doxorubicin (Dox). Highly hydrophobic cholesterol moieties as well as the drug were attached to the polymer backbone by a pH-sensitive hydrazone bond. Moreover, the structure of the spacer between the polymer carrier and the cholesterol moiety differed in order to influence the release rate of the hydrophobic moiety, and thus the disintegration of the highmolecular-weight micellar nanoparticle structure. We report kinetic studies of therapeutically highly potent polymerdrug conjugates consisting of amphiphilic N-(2-hydroxypropyl) methacrylamide (HPMA)-based copolymers bearing the anticancer drug doxorubicin (Dox). Highly hydrophobic cholesterol moieties as well as the drug were attached to the polymer backbone by a pH-sensitive hydrazone bond. Moreover, the structure of the spacer between the polymer carrier and the cholesterol moiety differed in order to influence the release rate of the hydrophobic moiety, and thus the disintegration of the highmolecular-weight micellar nanoparticle structure. (en)
Title	Hydrolytically degradable polymer micelles for drug delivery: a SAXS/SANS kinetic study Hydrolytically degradable polymer micelles for drug delivery: a SAXS/SANS kinetic study (en)
skos:prefLabel	Hydrolytically degradable polymer micelles for drug delivery: a SAXS/SANS kinetic study Hydrolytically degradable polymer micelles for drug delivery: a SAXS/SANS kinetic study (en)
skos:notation	RIV/61389013:_____/13:00398411!RIV14-GA0-61389013
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(GAP208/10/1600)
http://linked.open...iv/cisloPeriodika	11
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Štěpánek, Petr Ulbrich, Karel Chytil, Petr Etrych, Tomáš Filippov, Sergey Bogomolova, Anna
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav makromolekulární chemie AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	78493
http://linked.open...ai/riv/idVysledku	RIV/61389013:_____/13:00398411
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	HPMA; micelles; drug release (en)
http://linked.open.../riv/klicoveSlovo	micelles drug release HPMA
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[7BFFEEBE1920]
http://linked.open...i/riv/nazevZdroje	Biomacromolecules
http://linked.open...in/vavai/riv/obor	CF
http://linked.open...ichTvurcuVysledku	6 (xsd:int)
http://linked.open...cetTvurcuVysledku	12 (xsd:int)
http://linked.open...vavai/riv/projekt	Polymeric particles and nanostructured materials stabilized by surface active molecules
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	14
http://linked.open...iv/tvurceVysledku	Chytil, Petr Etrych, Tomáš Filippov, Sergey Ulbrich, Karel Štěpánek, Petr Bogomolova, Anna Dyakonova, M. Konarev, P. V. Papadakis, C. M. Svergun, D. I. Franklin, J. M. Radulescu, A.
http://linked.open...ain/vavai/riv/wos	000326955900027
issn	1525-7797
number of pages	10 (xsd:int)
http://bibframe.org/vocab/doi	10.1021/bm401186z

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