About: Biopolymer-based degradable nanofibres from renewable resources produced by freeze-drying     Goto   Sponge   NotDistinct   Permalink

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  • We describe a new biopolymer-based nanofibrous material possibly suitable for tissue engineering prepared by an environment-friendly organic solvent-free method. Glycogen, a biodegradable hyperbranched D-glucose polymer, comes from renewable resources and is normally present in man. It forms nanofibres by simple freeze-drying from aqueous solutions with concentration less than 0.5%. However, the architecture of the freeze-dried material depends on the starting biopolymer concentration within the tested range 0.1–5 wt%; in particular higher concentrations produce porous sponge-like structures with communicating pores. Because of the solubility of glycogen in water, nanofibres were modified by solvent-free grafting biodegradable poly(ethyl cyanoacrylate) from vapor phase. Exposing glycogen nanofibres to vapors of ethyl cyanoacrylate only slightly changed the material architecture while producing a water-insoluble biodegradable material with glycogen-to-poly(ethyl cyanoacrylate) ratio depending on the polymerization time. The material was proven to be hydrolytically degradable over the course of several months.
  • We describe a new biopolymer-based nanofibrous material possibly suitable for tissue engineering prepared by an environment-friendly organic solvent-free method. Glycogen, a biodegradable hyperbranched D-glucose polymer, comes from renewable resources and is normally present in man. It forms nanofibres by simple freeze-drying from aqueous solutions with concentration less than 0.5%. However, the architecture of the freeze-dried material depends on the starting biopolymer concentration within the tested range 0.1–5 wt%; in particular higher concentrations produce porous sponge-like structures with communicating pores. Because of the solubility of glycogen in water, nanofibres were modified by solvent-free grafting biodegradable poly(ethyl cyanoacrylate) from vapor phase. Exposing glycogen nanofibres to vapors of ethyl cyanoacrylate only slightly changed the material architecture while producing a water-insoluble biodegradable material with glycogen-to-poly(ethyl cyanoacrylate) ratio depending on the polymerization time. The material was proven to be hydrolytically degradable over the course of several months. (en)
Title
  • Biopolymer-based degradable nanofibres from renewable resources produced by freeze-drying
  • Biopolymer-based degradable nanofibres from renewable resources produced by freeze-drying (en)
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  • Biopolymer-based degradable nanofibres from renewable resources produced by freeze-drying
  • Biopolymer-based degradable nanofibres from renewable resources produced by freeze-drying (en)
skos:notation
  • RIV/61389013:_____/13:00394941!RIV14-GA0-61389013
http://linked.open...avai/riv/aktivita
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  • I, P(GA202/09/2078), P(GAP108/10/1560)
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  • 35
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  • 63537
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  • RIV/61389013:_____/13:00394941
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  • glycogen; nanofibres; poly(ethyl cyanoacrylate) (en)
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  • GB - Spojené království Velké Británie a Severního Irska
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  • [AB449F38F829]
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  • 3
http://linked.open...iv/tvurceVysledku
  • Hrubý, Martin
  • Přádný, Martin
  • Vetrík, Miroslav
  • Štěpánek, Petr
  • Šlouf, Miroslav
  • Kobera, Libor
  • Pospíšilová, Aneta
  • Rabyk, Mariia
http://linked.open...ain/vavai/riv/wos
  • 000323132100052
issn
  • 2046-2069
number of pages
http://bibframe.org/vocab/doi
  • 10.1039/c3ra42647e
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