About: PEG-modified magnetic hypercrosslinked poly(styrene-co-divinylbenzene) microspheres to minimize sorption of serum proteins

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Monodisperse poly(styrene-co-divinylbenzene) [P(St-DVB)] microspheres were prepared by the precipitation polymerization of styrene (St) and divinylbenzene (DVB) in acetonitrile (ACN). Effect of St/DVB ratio and monomer concentration on morphology and particle size was investigated. Monodisperse 4.1 m P(St-DVB) microspheres were chloromethylated with chloromethyl methyl ether (CMME) and hypercrosslinked using anhydrous FeCl3 as a catalyst to form a very fine porous structure and to introduce reactive chloromethyl groups in the resulting product denoted as HC-P(St-DVB) particles. The hypercrosslinked microspheres were then functionalized with amino groups to yield HC-P(St-DVB)-NH2 particles and iron oxide was precipitated within their pores. The obtained microparticles were highly magnetic with iron content 38 wt% Fe. The surface of the magnetic microspheres was newly hydrophilized with methoxy-poly(ethylene glycol) (methoxy-PEG) which was confirmed by ATR FT-IR spectroscopy. The poly(ethylene glycol) (PEG)-modified magnetic microspheres were investigated in terms of sorption of serum proteins under different conditions and compared with the sorption on neat magnetic HC-P(St-DVB)-NH2 particles. The surface modification of magnetic microspheres significantly minimized the adsorption of the serum proteins. Monodisperse poly(styrene-co-divinylbenzene) [P(St-DVB)] microspheres were prepared by the precipitation polymerization of styrene (St) and divinylbenzene (DVB) in acetonitrile (ACN). Effect of St/DVB ratio and monomer concentration on morphology and particle size was investigated. Monodisperse 4.1 m P(St-DVB) microspheres were chloromethylated with chloromethyl methyl ether (CMME) and hypercrosslinked using anhydrous FeCl3 as a catalyst to form a very fine porous structure and to introduce reactive chloromethyl groups in the resulting product denoted as HC-P(St-DVB) particles. The hypercrosslinked microspheres were then functionalized with amino groups to yield HC-P(St-DVB)-NH2 particles and iron oxide was precipitated within their pores. The obtained microparticles were highly magnetic with iron content 38 wt% Fe. The surface of the magnetic microspheres was newly hydrophilized with methoxy-poly(ethylene glycol) (methoxy-PEG) which was confirmed by ATR FT-IR spectroscopy. The poly(ethylene glycol) (PEG)-modified magnetic microspheres were investigated in terms of sorption of serum proteins under different conditions and compared with the sorption on neat magnetic HC-P(St-DVB)-NH2 particles. The surface modification of magnetic microspheres significantly minimized the adsorption of the serum proteins. (en)
Title	PEG-modified magnetic hypercrosslinked poly(styrene-co-divinylbenzene) microspheres to minimize sorption of serum proteins PEG-modified magnetic hypercrosslinked poly(styrene-co-divinylbenzene) microspheres to minimize sorption of serum proteins (en)
skos:prefLabel	PEG-modified magnetic hypercrosslinked poly(styrene-co-divinylbenzene) microspheres to minimize sorption of serum proteins PEG-modified magnetic hypercrosslinked poly(styrene-co-divinylbenzene) microspheres to minimize sorption of serum proteins (en)
skos:notation	RIV/61389013:_____/13:00392996!RIV14-GA0-61389013
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(GAP206/12/0381), P(GCP207/12/J013)
http://linked.open...iv/cisloPeriodika	8
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Bláha, Michal Horák, Daniel Šálek, Petr
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav makromolekulární chemie AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	95666
http://linked.open...ai/riv/idVysledku	RIV/61389013:_____/13:00392996
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	hypercrosslinked; magnetic; microsphere (en)
http://linked.open.../riv/klicoveSlovo	microsphere magnetic hypercrosslinked
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[FBEFC5AF5BA2]
http://linked.open...i/riv/nazevZdroje	Reactive and Functional Polymers
http://linked.open...in/vavai/riv/obor	CD
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...vavai/riv/projekt	Development of ultrasensitive electrochemical immunosensors for early detection of clinically significant biomarkers of malignant diseases Innovative multifunctional magnetic nano- and microparticles for cell diagnostics
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	73
http://linked.open...iv/tvurceVysledku	Bláha, Michal Horák, Daniel Šálek, Petr
http://linked.open...ain/vavai/riv/wos	000322101400017
issn	1381-5148
number of pages	8 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.reactfunctpolym.2013.05.011

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