About: The use of hydrophilic poly(N,N-dimethylacrylamide) for promoting engulfment of magnetic .gamma.-Fe2O3 nanoparticles by mammalian cells

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Gamma-Fe2O3 nanoparticles obtained by coprecipitation of Fe(II) and Fe(III) chlorides with a base and subsequent oxidation were coated with a shell of hydrophilic biocompatible poly(N,N-dimethylacrylamide) (PDMAAm). Various initiators were attached to the iron oxide surface to enable the use of the “grafting-from“ approach for immobilization of PDMAAm. They included 2,2-azobis(2-methylpropanimidamide) dihydrochloride (AMPA), 2,2-azobis(N-hydroxy-2-methylpropanimidamide) dihydrochloride (ABHA) and 4-cyano-4-{[1-cyano-3-(N-hydroxycarbamoyl)-1-methylpropyl]azo}pentanoic acid (CCHPA). Engulfment of PDMAAm-coated γ-Fe2O3 nanoparticles by murine J774.2 macrophages was investigated. Only some nanoparticles were engulfed by the macrophages. PDMAAm-AMPA-γ-Fe2O3 and PDMAAm-ABHA-γ-Fe2O3 nanoparticles were rapidly engulfed by the cells. In contrast, neat γ-Fe2O3 and PDMAAm-CCHPA-γ-Fe2O3 particles induced formation of transparent vacuoles indicating toxicity of the particles. Thus, PDMAAm-coated AMPA- and ABHA-γ-Fe2O3 nanoparticles can be recommended as non-toxic labels for mammalian cells. Gamma-Fe2O3 nanoparticles obtained by coprecipitation of Fe(II) and Fe(III) chlorides with a base and subsequent oxidation were coated with a shell of hydrophilic biocompatible poly(N,N-dimethylacrylamide) (PDMAAm). Various initiators were attached to the iron oxide surface to enable the use of the “grafting-from“ approach for immobilization of PDMAAm. They included 2,2-azobis(2-methylpropanimidamide) dihydrochloride (AMPA), 2,2-azobis(N-hydroxy-2-methylpropanimidamide) dihydrochloride (ABHA) and 4-cyano-4-{[1-cyano-3-(N-hydroxycarbamoyl)-1-methylpropyl]azo}pentanoic acid (CCHPA). Engulfment of PDMAAm-coated γ-Fe2O3 nanoparticles by murine J774.2 macrophages was investigated. Only some nanoparticles were engulfed by the macrophages. PDMAAm-AMPA-γ-Fe2O3 and PDMAAm-ABHA-γ-Fe2O3 nanoparticles were rapidly engulfed by the cells. In contrast, neat γ-Fe2O3 and PDMAAm-CCHPA-γ-Fe2O3 particles induced formation of transparent vacuoles indicating toxicity of the particles. Thus, PDMAAm-coated AMPA- and ABHA-γ-Fe2O3 nanoparticles can be recommended as non-toxic labels for mammalian cells. (en)
Title	The use of hydrophilic poly(N,N-dimethylacrylamide) for promoting engulfment of magnetic .gamma.-Fe2O3 nanoparticles by mammalian cells The use of hydrophilic poly(N,N-dimethylacrylamide) for promoting engulfment of magnetic .gamma.-Fe2O3 nanoparticles by mammalian cells (en)
skos:prefLabel	The use of hydrophilic poly(N,N-dimethylacrylamide) for promoting engulfment of magnetic .gamma.-Fe2O3 nanoparticles by mammalian cells The use of hydrophilic poly(N,N-dimethylacrylamide) for promoting engulfment of magnetic .gamma.-Fe2O3 nanoparticles by mammalian cells (en)
skos:notation	RIV/61389013:_____/13:00391930!RIV14-MSM-61389013
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(7E12053), P(GAP206/12/0381)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Trchová, Miroslava Horák, Daniel Macková, Hana Hromádková, Jiřina Babič, Michal Beneš, Milan J. Zasońska, Beata Anna
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav makromolekulární chemie AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	112994
http://linked.open...ai/riv/idVysledku	RIV/61389013:_____/13:00391930
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	maghemite; core-shell; nanoparticles (en)
http://linked.open.../riv/klicoveSlovo	maghemite core-shell nanoparticles
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[BDDF696360AE]
http://linked.open...i/riv/nazevZdroje	Journal of Biomedical Nanotechnology
http://linked.open...in/vavai/riv/obor	CD
http://linked.open...ichTvurcuVysledku	7 (xsd:int)
http://linked.open...cetTvurcuVysledku	10 (xsd:int)
http://linked.open...vavai/riv/projekt	Development of ultrasensitive electrochemical immunosensors for early detection of clinically significant biomarkers of malignant diseases Nanosystems for early Diagnosis of Neurodegenerative Diseases
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	9
http://linked.open...iv/tvurceVysledku	Horák, Daniel Trchová, Miroslava Beneš, Milan J. Macková, Hana Hromádková, Jiřina Babič, Michal Boiko, N. Klyuchivska, O. Stoika, R. Zasońska, Beata Anna
http://linked.open...ain/vavai/riv/wos	000316040500019
issn	1550-7033
number of pages	13 (xsd:int)
http://bibframe.org/vocab/doi	10.1166/jbn.2013.1552

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