About: Novel polymeric nanoparticles assembled by metal ion addition

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Potentially biodegradable graft polymer core-shell nanoparticles assembling by addition of metal ions intended to be used for radionuclide and drug delivery purposes are described. With Cu2+ ions, the self-assembly is slow (within minutes) with low efficiency. With Fe3+ ions the nanoparticles are formed immediately and are of convenient size for passive tumor accumulation by the enhanced permeation and retention effect. Full in vitro degradation of these particles is achieved with deferoxamine as a model of in vivo transchelation capacity. Potentially biodegradable graft polymer core-shell nanoparticles assembling by addition of metal ions intended to be used for radionuclide and drug delivery purposes are described. With Cu2+ ions, the self-assembly is slow (within minutes) with low efficiency. With Fe3+ ions the nanoparticles are formed immediately and are of convenient size for passive tumor accumulation by the enhanced permeation and retention effect. Full in vitro degradation of these particles is achieved with deferoxamine as a model of in vivo transchelation capacity. (en)
Title	Novel polymeric nanoparticles assembled by metal ion addition Novel polymeric nanoparticles assembled by metal ion addition (en)
skos:prefLabel	Novel polymeric nanoparticles assembled by metal ion addition Novel polymeric nanoparticles assembled by metal ion addition (en)
skos:notation	RIV/61389013:_____/11:00366448!RIV12-AV0-61389013
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(1M0505), P(GA202/09/2078), P(GPP207/10/P054), Z(AV0Z40500505)
http://linked.open...iv/cisloPeriodika	21
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Štěpánek, Petr Ulbrich, Karel Špírková, Milena Hrubý, Martin Macková, Hana Škodová, Michaela Steinhart, Miloš Kaňková, Dana Filippov, Sergey
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav makromolekulární chemie AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	216605
http://linked.open...ai/riv/idVysledku	RIV/61389013:_____/11:00366448
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	drug delivery systems; hydroxamic acid; nanoparticles (en)
http://linked.open.../riv/klicoveSlovo	nanoparticles drug delivery systems hydroxamic acid
http://linked.open...odStatuVydavatele	DE - Spolková republika Německo
http://linked.open...ontrolniKodProRIV	[923614D874A9]
http://linked.open...i/riv/nazevZdroje	Macromolecular Chemistry and Physics
http://linked.open...in/vavai/riv/obor	CD
http://linked.open...ichTvurcuVysledku	9 (xsd:int)
http://linked.open...cetTvurcuVysledku	10 (xsd:int)
http://linked.open...vavai/riv/projekt	Center of targeted therapeutic drugs Polymeric micelles with metal ion – assembled core Bioinspired nanoparticles sensitive to environment stimuli
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	212
http://linked.open...iv/tvurceVysledku	Filippov, Sergey Hrubý, Martin Ulbrich, Karel Štěpánek, Petr Špírková, Milena Macková, Hana Škodová, Michaela Karlsson, G. Kaňková, Dana Steinhart, Miloš
http://linked.open...ain/vavai/riv/wos	000297411600006
http://linked.open...n/vavai/riv/zamer	Progresivní makromolekulární materiály a supramolekulární systémy: syntéza a studium vlastností, jevů a možností využití pro speciální aplikace a moderní technologie
issn	1022-1352
number of pages	10 (xsd:int)
http://bibframe.org/vocab/doi	10.1002/macp.201100431

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