About: New perspectives of 19F MAS NMR in the characterization of amorphous forms of atorvastatin in dosage formulations

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About: New perspectives of 19F MAS NMR in the characterization of amorphous forms of atorvastatin in dosage formulations Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Despite recent advances in solid-state NMR, the structural characterization of amorphous pharmaceuticals (APIs) in solid dosage forms continues to be a monumental challenge. To circumvent complications following from low concentrations of APIs in tablet formulations, we propose a new time-saving procedure based on chemometric approach: factor analysis of 19F MAS NMR spectra. Capability of the proposed method is demonstrated on atorvastatin – a typical representative of fluorinated pharmaceutical substances exhibiting extensive polymorphism. Applying the factor analysis on the recorded 19F MAS NMR spectra, unique parameters for every sample were derived. In this way every solid form of atorvastatin was characterized and clearly distinguishable even among various amorphous and disordered forms. Reliability of the proposed method was examined by comparing with other techniques and perspectives to obtain structural view on variability of amorphous products are also discussed. Despite recent advances in solid-state NMR, the structural characterization of amorphous pharmaceuticals (APIs) in solid dosage forms continues to be a monumental challenge. To circumvent complications following from low concentrations of APIs in tablet formulations, we propose a new time-saving procedure based on chemometric approach: factor analysis of 19F MAS NMR spectra. Capability of the proposed method is demonstrated on atorvastatin – a typical representative of fluorinated pharmaceutical substances exhibiting extensive polymorphism. Applying the factor analysis on the recorded 19F MAS NMR spectra, unique parameters for every sample were derived. In this way every solid form of atorvastatin was characterized and clearly distinguishable even among various amorphous and disordered forms. Reliability of the proposed method was examined by comparing with other techniques and perspectives to obtain structural view on variability of amorphous products are also discussed. (en)
Title	New perspectives of 19F MAS NMR in the characterization of amorphous forms of atorvastatin in dosage formulations New perspectives of 19F MAS NMR in the characterization of amorphous forms of atorvastatin in dosage formulations (en)
skos:prefLabel	New perspectives of 19F MAS NMR in the characterization of amorphous forms of atorvastatin in dosage formulations New perspectives of 19F MAS NMR in the characterization of amorphous forms of atorvastatin in dosage formulations (en)
skos:notation	RIV/61389013:_____/11:00359458!RIV12-AV0-61389013
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(2B08021), Z(AV0Z40500505)
http://linked.open...iv/cisloPeriodika	1/2
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Urbanová, Martina Šeděnková, Ivana Brus, Jiří
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav makromolekulární chemie AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	215859
http://linked.open...ai/riv/idVysledku	RIV/61389013:_____/11:00359458
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	19F MAS NMR; factor analysis; polymorphism (en)
http://linked.open.../riv/klicoveSlovo	factor analysis polymorphism 19F MAS NMR
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[4BC01FEAF66A]
http://linked.open...i/riv/nazevZdroje	International Journal of Pharmaceutics
http://linked.open...in/vavai/riv/obor	CB
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	NMR crystallography of active pharmaceuticals ingredients for industrial applications
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	409
http://linked.open...iv/tvurceVysledku	Urbanová, Martina Šeděnková, Ivana Brus, Jiří Brusová, H.
http://linked.open...ain/vavai/riv/wos	000290135800008
http://linked.open...n/vavai/riv/zamer	Progresivní makromolekulární materiály a supramolekulární systémy: syntéza a studium vlastností, jevů a možností využití pro speciální aplikace a moderní technologie
issn	0378-5173
number of pages	13 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.ijpharm.2011.02.030

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