About: A new type of irreversibly reductively biodegradable hydrogel

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Reductively biodegradable hydrogels based on poly[N-(2-hydroxypropyl)methacrylamide] crosslinked with N-[3-(methacryloylamino)propyl] -6-{[5-({[3-(methacryloylamino)propyl]amino}carbonyl)-2-pyridyl]disulfanyl}nicotinamide intended for tissue engineering were synthesized and characterized. The rate of irreversible reductive degradation with thiol l-cysteine (a model of human body where several thiols are present in extracellular space) was studied using several l-cysteine concentrations. The mechanism of the irreversible reductive bond cleavage in the crosslinker structure was confirmed on a low-molecular-weight model. The hydrogel is stable during storage in phosphate buffered saline and is degraded relatively quickly in a concentration-dependent manner after addition of l-cysteine to the surrounding medium. Reductively biodegradable hydrogels based on poly[N-(2-hydroxypropyl)methacrylamide] crosslinked with N-[3-(methacryloylamino)propyl] -6-{[5-({[3-(methacryloylamino)propyl]amino}carbonyl)-2-pyridyl]disulfanyl}nicotinamide intended for tissue engineering were synthesized and characterized. The rate of irreversible reductive degradation with thiol l-cysteine (a model of human body where several thiols are present in extracellular space) was studied using several l-cysteine concentrations. The mechanism of the irreversible reductive bond cleavage in the crosslinker structure was confirmed on a low-molecular-weight model. The hydrogel is stable during storage in phosphate buffered saline and is degraded relatively quickly in a concentration-dependent manner after addition of l-cysteine to the surrounding medium. (en)
Title	A new type of irreversibly reductively biodegradable hydrogel A new type of irreversibly reductively biodegradable hydrogel (en)
skos:prefLabel	A new type of irreversibly reductively biodegradable hydrogel A new type of irreversibly reductively biodegradable hydrogel (en)
skos:notation	RIV/61389013:_____/11:00359453!RIV12-AV0-61389013
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(1M0538), P(GAP108/10/1560), P(GPP207/10/P054), Z(AV0Z40500505)
http://linked.open...iv/cisloPeriodika	5
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Hrubý, Martin Michálek, Jiří Přádný, Martin Vetrík, Miroslav
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav makromolekulární chemie AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	183982
http://linked.open...ai/riv/idVysledku	RIV/61389013:_____/11:00359453
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	biodegradable hydrogel; disulfide; L-cysteine (en)
http://linked.open.../riv/klicoveSlovo	L-cysteine biodegradable hydrogel disulfide
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[A49201EDF047]
http://linked.open...i/riv/nazevZdroje	Polymer Degradation and Stability
http://linked.open...in/vavai/riv/obor	CD
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Center for Cell Therapy and Tissue Repair New generation of reductively biodegradable functionalized macroporous scaffolds for neural tissue engineering Polymeric micelles with metal ion – assembled core
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	96
http://linked.open...iv/tvurceVysledku	Hrubý, Martin Michálek, Jiří Přádný, Martin Vetrík, Miroslav
http://linked.open...ain/vavai/riv/wos	000290078200021
http://linked.open...n/vavai/riv/zamer	Progresivní makromolekulární materiály a supramolekulární systémy: syntéza a studium vlastností, jevů a možností využití pro speciální aplikace a moderní technologie
issn	0141-3910
number of pages	6 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.polymdegradstab.2011.01.037

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