About: Biodegradable star HPMA polymer conjugates of doxorubicin for passive tumor targeting

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Biodegradable star HPMA polymer conjugates of doxorubicin for passive tumor targeting Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	New biodegradable star polymer–doxorubicin conjugates designed for passive tumor targeting were investigated and the present study described their synthesis, physico-chemical characterization, drug release and biodegradation. In the conjugates the core formed by poly(amido amine) dendrimers was grafted with semitelechelic N-(2-hydroxypropyl)methacrylamide copolymers bearing doxorubicin attached by hydrazone bonds, which enabled intracellular pH-controlled drug release, or by a GFLG sequence, which was susceptible to enzymatic degradation. The controlled synthesis utilizing semitelechelic copolymer precursors facilitated preparation of biodegradable polymer conjugates in a broad range of molecular weights (110–295 kD). The polymer grafts were attached to the dendrimers either through stable amide bonds or enzymatically or reductively degradable spacers, which enabled intracellular degradation of the HMW polymer carrier to products that were able to be excreted by glomerular filtration. New biodegradable star polymer–doxorubicin conjugates designed for passive tumor targeting were investigated and the present study described their synthesis, physico-chemical characterization, drug release and biodegradation. In the conjugates the core formed by poly(amido amine) dendrimers was grafted with semitelechelic N-(2-hydroxypropyl)methacrylamide copolymers bearing doxorubicin attached by hydrazone bonds, which enabled intracellular pH-controlled drug release, or by a GFLG sequence, which was susceptible to enzymatic degradation. The controlled synthesis utilizing semitelechelic copolymer precursors facilitated preparation of biodegradable polymer conjugates in a broad range of molecular weights (110–295 kD). The polymer grafts were attached to the dendrimers either through stable amide bonds or enzymatically or reductively degradable spacers, which enabled intracellular degradation of the HMW polymer carrier to products that were able to be excreted by glomerular filtration. (en)
Title	Biodegradable star HPMA polymer conjugates of doxorubicin for passive tumor targeting Biodegradable star HPMA polymer conjugates of doxorubicin for passive tumor targeting (en)
skos:prefLabel	Biodegradable star HPMA polymer conjugates of doxorubicin for passive tumor targeting Biodegradable star HPMA polymer conjugates of doxorubicin for passive tumor targeting (en)
skos:notation	RIV/61389013:_____/11:00359227!RIV12-AV0-61389013
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA203/08/0543), P(IAA400500806), P(IAAX00500803), Z(AV0Z40500505)
http://linked.open...iv/cisloPeriodika	5
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Strohalm, Jiří Ulbrich, Karel Pechar, Michal Chytil, Petr Černoch, Peter Etrych, Tomáš Starovoytova, Larisa
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav makromolekulární chemie AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	188271
http://linked.open...ai/riv/idVysledku	RIV/61389013:_____/11:00359227
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	dendrimer; HPMA copolymers; doxorubicin (en)
http://linked.open.../riv/klicoveSlovo	doxorubicin HPMA copolymers dendrimer
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[7367601DF310]
http://linked.open...i/riv/nazevZdroje	European Journal of Pharmaceutical Sciences
http://linked.open...in/vavai/riv/obor	CD
http://linked.open...ichTvurcuVysledku	7 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	Hybrid macromolecular systems based on hydrophilic polymers and stimuli-responsive peptides Branched and hyperbranched polymer carriers of drugs for local therapy Multifunctional Polymer Systems with Cytostatic and Immunomobilizing Activities
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	42
http://linked.open...iv/tvurceVysledku	Chytil, Petr Etrych, Tomáš Pechar, Michal Starovoytova, Larisa Strohalm, Jiří Ulbrich, Karel Černoch, Peter
http://linked.open...ain/vavai/riv/wos	000290822800012
http://linked.open...n/vavai/riv/zamer	Progresivní makromolekulární materiály a supramolekulární systémy: syntéza a studium vlastností, jevů a možností využití pro speciální aplikace a moderní technologie
issn	0928-0987
number of pages	13 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.ejps.2011.03.001

Faceted Search & Find service v1.16.118 as of Jun 21 2024

Alternative Linked Data Documents: ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 48 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software