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  • Homopolymer poly(HPMA) was originally developed as a blood expander “Duxon. Later on, linear Nondegradable HPMA copolymer of a molecular weight 25kDa was used as the backbone to which drugs, mostly doxorubicin, were attached through different side chains and different covalent bonds. Non-targeted and targeted polymer–drug derivatives based on HPMA have both cytostatic and immunostimulating activity. Their impressive anti-tumor effects most likely result from the combination of strong direct cytotoxicity and a systemic anticancer resistance regularly induced during the treatment
  • Homopolymer poly(HPMA) was originally developed as a blood expander “Duxon. Later on, linear Nondegradable HPMA copolymer of a molecular weight 25kDa was used as the backbone to which drugs, mostly doxorubicin, were attached through different side chains and different covalent bonds. Non-targeted and targeted polymer–drug derivatives based on HPMA have both cytostatic and immunostimulating activity. Their impressive anti-tumor effects most likely result from the combination of strong direct cytotoxicity and a systemic anticancer resistance regularly induced during the treatment (en)
Title
  • HPMA – Anticancer Drug Conjugates
  • HPMA – Anticancer Drug Conjugates (en)
skos:prefLabel
  • HPMA – Anticancer Drug Conjugates
  • HPMA – Anticancer Drug Conjugates (en)
skos:notation
  • RIV/61389013:_____/10:00350338!RIV11-MSM-61389013
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(1M0505), P(IAAX00500803), P(KAN200200651), Z(AV0Z40500505), Z(AV0Z50200510)
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
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http://linked.open...dnocenehoVysledku
  • 262221
http://linked.open...ai/riv/idVysledku
  • RIV/61389013:_____/10:00350338
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • hpma; doxorubicin; cytotoxicity (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...ontrolniKodProRIV
  • [1C85703B2B67]
http://linked.open...i/riv/mistoVydani
  • New York
http://linked.open...i/riv/nazevZdroje
  • Macromolecular Anticancer Therapeutics
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...v/pocetStranKnihy
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http://linked.open...iv/tvurceVysledku
  • Kovář, Lubomír
  • Kovář, Marek
  • Ulbrich, Karel
  • Říhová, Blanka
  • Šírová, Milada
  • Šubr, Vladimír
  • Hovorka, Ondřej
  • Mrkvan, Tomáš
http://linked.open...n/vavai/riv/zamer
number of pages
http://purl.org/ne...btex#hasPublisher
  • Springer-Verlag
https://schema.org/isbn
  • 978-1-4419-0506-2
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