About: Multi-component polymeric system for tumour cell-specific gene delivery using a universal bungarotoxin linker

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About: Multi-component polymeric system for tumour cell-specific gene delivery using a universal bungarotoxin linker Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	A new universal tool for specific, non-covalent and non-destructive attachment of a recombinant antibody fragment to a polymer-modified adenovirus has been utilised to regulate the tropism of adenoviral gene delivery vector. We have prepared a multivalent reactive N-(2-hydroxypropyl)methacrylamide-based copolymer (PHPMA) bearing an alpha-bungarotoxin-binding peptide (BTXbp). The copolymer was used for covalent surface modification of adenoviral vectors (Ad). A single chain variable fragment of anti-PSMA antibody bearing bungarotoxin (scFv-BTX) binding to the prostate-specific membrane antigen (PSMA) was conjugated with the copolymer-coated Ad. The presented Ad-PHPMA-BTXbp/scFv-BTX system can be used as a universal tool for a receptor-specific virotherapy. A new universal tool for specific, non-covalent and non-destructive attachment of a recombinant antibody fragment to a polymer-modified adenovirus has been utilised to regulate the tropism of adenoviral gene delivery vector. We have prepared a multivalent reactive N-(2-hydroxypropyl)methacrylamide-based copolymer (PHPMA) bearing an alpha-bungarotoxin-binding peptide (BTXbp). The copolymer was used for covalent surface modification of adenoviral vectors (Ad). A single chain variable fragment of anti-PSMA antibody bearing bungarotoxin (scFv-BTX) binding to the prostate-specific membrane antigen (PSMA) was conjugated with the copolymer-coated Ad. The presented Ad-PHPMA-BTXbp/scFv-BTX system can be used as a universal tool for a receptor-specific virotherapy. (en)
Title	Multi-component polymeric system for tumour cell-specific gene delivery using a universal bungarotoxin linker Multi-component polymeric system for tumour cell-specific gene delivery using a universal bungarotoxin linker (en)
skos:prefLabel	Multi-component polymeric system for tumour cell-specific gene delivery using a universal bungarotoxin linker Multi-component polymeric system for tumour cell-specific gene delivery using a universal bungarotoxin linker (en)
skos:notation	RIV/61389013:_____/10:00349126!RIV11-GA0-61389013
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA203/08/0543), P(KAN200200651), Z(AV0Z40500505)
http://linked.open...iv/cisloPeriodika	11
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Ulbrich, Karel Pechar, Michal Pola, Robert
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav makromolekulární chemie AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	273068
http://linked.open...ai/riv/idVysledku	RIV/61389013:_____/10:00349126
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	adenovirus; hydrophilic polymers; tumour targeting (en)
http://linked.open.../riv/klicoveSlovo	tumour targeting adenovirus hydrophilic polymers
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[19E5A771790D]
http://linked.open...i/riv/nazevZdroje	Pharmaceutical Research
http://linked.open...in/vavai/riv/obor	CD
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...vavai/riv/projekt	Hybrid macromolecular systems based on hydrophilic polymers and stimuli-responsive peptides Nanoparticulate and supramolecular systems for targeted drug delivery
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	27
http://linked.open...iv/tvurceVysledku	Pechar, Michal Pola, Robert Ulbrich, Karel Seymour, L. W. Carlisle, R. C. Willemsen, R. A. Schooten, E. Thompson, A. J.
http://linked.open...ain/vavai/riv/wos	000283368000003
http://linked.open...n/vavai/riv/zamer	Progresivní makromolekulární materiály a supramolekulární systémy: syntéza a studium vlastností, jevů a možností využití pro speciální aplikace a moderní technologie
issn	0724-8741
number of pages	9 (xsd:int)

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