About: Core-crosslinked polymeric micelles with controlled release of covalently entrapped doxorubicin

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About: Core-crosslinked polymeric micelles with controlled release of covalently entrapped doxorubicin Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	A physically entrapped anticancer drug (paclitaxel) was previously shown to be rapidly eliminated from the circulation, likely because the drug was insufficiently retained in the micelles. To fully exploit the EPR effect for drug targeting, a DOX methacrylamide derivative (DOX-MA) was covalently incorporated into the micellar core by free radical polymerization. The structure of the doxorubicin derivative is susceptible to pH-sensitive hydrolysis, enabling controlled release of the drug in acidic conditions (in either the intratumoral environment and/or the endosomal vesicles). The entire drug payload was released within 24 h incubation at pH 5 and 37 °C, whereas only around 5% release was observed at pH 7.4. DOX micelles showed higher cytotoxicity in B16F10 and OVCAR-3 cells compared to DOX-MA, likely due to cellular uptake of the micelles via endocytosis and intracellular drug release in the acidic organelles. A physically entrapped anticancer drug (paclitaxel) was previously shown to be rapidly eliminated from the circulation, likely because the drug was insufficiently retained in the micelles. To fully exploit the EPR effect for drug targeting, a DOX methacrylamide derivative (DOX-MA) was covalently incorporated into the micellar core by free radical polymerization. The structure of the doxorubicin derivative is susceptible to pH-sensitive hydrolysis, enabling controlled release of the drug in acidic conditions (in either the intratumoral environment and/or the endosomal vesicles). The entire drug payload was released within 24 h incubation at pH 5 and 37 °C, whereas only around 5% release was observed at pH 7.4. DOX micelles showed higher cytotoxicity in B16F10 and OVCAR-3 cells compared to DOX-MA, likely due to cellular uptake of the micelles via endocytosis and intracellular drug release in the acidic organelles. (en)
Title	Core-crosslinked polymeric micelles with controlled release of covalently entrapped doxorubicin Core-crosslinked polymeric micelles with controlled release of covalently entrapped doxorubicin (en)
skos:prefLabel	Core-crosslinked polymeric micelles with controlled release of covalently entrapped doxorubicin Core-crosslinked polymeric micelles with controlled release of covalently entrapped doxorubicin (en)
skos:notation	RIV/61389013:_____/10:00346588!RIV11-AV0-61389013
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(IAA400500806), P(KAN200200651), Z(AV0Z40500505)
http://linked.open...iv/cisloPeriodika	30
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Ulbrich, Karel Etrych, Tomáš
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav makromolekulární chemie AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	252167
http://linked.open...ai/riv/idVysledku	RIV/61389013:_____/10:00346588
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	doxorubicin; cancer therapy; polymeric micelle (en)
http://linked.open.../riv/klicoveSlovo	polymeric micelle doxorubicin cancer therapy
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[3FAA5BDC8344]
http://linked.open...i/riv/nazevZdroje	Biomaterials
http://linked.open...in/vavai/riv/obor	CD
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	11 (xsd:int)
http://linked.open...vavai/riv/projekt	Nanoparticulate and supramolecular systems for targeted drug delivery Branched and hyperbranched polymer carriers of drugs for local therapy
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	31
http://linked.open...iv/tvurceVysledku	Etrych, Tomáš Ulbrich, Karel Lammers, T. Storm, G. Hennink, W. E. Rijcken, C. J. F. Talelli, M. Iman, M. Schiffelers, R. M. Varkouhi, A. K. van Nostrum, C. F.
http://linked.open...ain/vavai/riv/wos	000281498600021
http://linked.open...n/vavai/riv/zamer	Progresivní makromolekulární materiály a supramolekulární systémy: syntéza a studium vlastností, jevů a možností využití pro speciální aplikace a moderní technologie
issn	0142-9612
number of pages	8 (xsd:int)

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